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Displaying results 5511 - 5520 of 10000 in total
  1. Drug

    Axitinib

    go.drugbank.com/drugs/DB06626
    ApprovedInvestigational

    [A179398] It is most commonly marketed under the name Inlyta® and is available in oral formulations. … It is reported to exhibit potency that is 50-450 times higher than that of the first generation VEGFR inhibitors.[L6676] Axitinib is an indazole derivative.

    Synonyms: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
  2. Drug

    Oportuzumab monatox

    go.drugbank.com/drugs/DB05319
    Investigational

    VB4-845 is a fusion protein containing humanized scFv specific for the epithelial cell adhesion molecule, Ep-CAM, a tumor cell-associated target highly expressed on carcinoma cells of epithelial origin … VB4-845 is studied in the treatment of certain types of head and neck cancer. VB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells.

  3. Target

    Human Vascular Endothelial Growth Factors (VEGFs)

    go.drugbank.com/bio_entities/BE0010103
    TargetHumans

    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis … Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969).

    Polypeptides: Vascular endothelial growth factor A, long formSynonyms: c-Fos-induced growth factor
  4. Drug

    SAB-185

    go.drugbank.com/drugs/DB16491
    Investigational

    Synonyms: HUMAN IGG POLYCLONAL ANTIBODY DERIVED FROM PLASMA OF TRANSCHROMOSOMAL BOVINE TARGETED TO THE SPIKE PROTEIN OF SARS COV-2Categories: Experimental Unapproved Treatments for COVID-19
  5. Drug

    V-SARS

    go.drugbank.com/drugs/DB15812
    Investigational

    Immunitor Inc., the sponsor, is currently testing this oral vaccine for immunogenicity in 20 healthy volunteers in a Phase 1 clinical trial (NCT04380532). … This therapeutic concept was applied to the development of V-SARS, which heat inactivates the plasma, and packages it into a once-daily pill form.

  6. Drug

    Spermine

    go.drugbank.com/drugs/DB00127
    InvestigationalNutraceutical

    Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. … Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species.

    Synonyms: N,N'-Bis(3-aminopropyl)-1,4-butanediamine
  7. Drug

    PRTX-100

    go.drugbank.com/drugs/DB05947
    Investigational

    PRTX-100 is a highly-purified form of Staphylococcal Protein A that binds directly to monocytes and a subset of B-cells that are involved in the development and progression of various autoimmune diseases … These binding interactions enable the compound to modulate the function of these cells and restore the balance of the immune system.

  8. Drug

    OXI-4503

    go.drugbank.com/drugs/DB05143
    Investigational

    OXI-4503 is investigated in clinical trials for treating cancer/tumors. OXI-4503 is a solid. OXI-4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. … to an orthoquinone chemical species that has direct cytotoxic effects on tumor cells.

  9. Drug

    STC3141

    go.drugbank.com/drugs/DB16475
    Investigational

    STC3141, was investigated in clinical trial NCT04880694 to evaluate its safety and effect in subjects with severe COVID-19 pneumonia.

    Categories: Experimental Unapproved Treatments for COVID-19
  10. Drug

    Levotofisopam

    go.drugbank.com/drugs/DB19073
    Investigational

    Levotofisopam is under investigation in clinical trial NCT01519687 (Study of Levotofisopam 50 Mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout).