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Chikungunya virus Senegal strain 37997 capsid protein
go.drugbank.com/drugs/DB21766ApprovedInvestigationalOne of three components of a recombinant Chikungunya virus vaccine called Vimkunya.
Chikungunya virus Senegal strain 37997 envelope protein E2
go.drugbank.com/drugs/DB21768ApprovedInvestigationalOne of three components of a recombinant Chikungunya virus vaccine called Vimkunya.
Palivizumab
go.drugbank.com/drugs/DB00110ApprovedInvestigationalThe human lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene K104 withJk-4. … Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV).
Sotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigational[L34288] This mutation makes up >50% of all KRAS mutations.[A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s. … Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.
Tocofersolan
go.drugbank.com/drugs/DB11635ApprovedIt was approved by the European Medicines Agency (EMA) in June 2009 under the market name Vedrop. … Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by _hepatocytes_ (liver cells) or obstruction [L2374], [L2375].
Diazoxide
go.drugbank.com/drugs/DB01119ApprovedInvestigational[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. … [A190372] When administered intravenously, diazoxide can be used to treat hypertensive emergencies;[L44622] however, this specific form of diazoxide is no longer available in the US.
Adalimumab
go.drugbank.com/drugs/DB00051ApprovedInvestigational[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA.[A39983] This drug is frequently known as _Humira_. … Adalimumab-atto was the first adalimumab biosimilar approved by the FDA in 2016.[L44953] Adalimumab-adaz was approved by the FDA on October 31, 2018.
Avatrombopag
go.drugbank.com/drugs/DB11995ApprovedInvestigationalDoptelet Sprinkle (avatrombopag oral granules), specifically designed for children aged one to less than six years, while the existing tablet formulation remains indicated for patients aged six years and older … [F95] Avatrombopag was first approved by the FDA in May 2018 for use in adults with chronic liver disease who are scheduled to undergo a procedure.
Levonorgestrel
go.drugbank.com/drugs/DB00367ApprovedInvestigationalinitially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older
Telithromycin
go.drugbank.com/drugs/DB00976ApprovedSimilar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. … Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one.