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Displaying results 551 - 560 of 912 in total
  1. Target

    Serine/threonine-protein kinase SIK3

    go.drugbank.com/bio_entities/BE0009454
    TargetHumans

    Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). ...

    Synonyms: Salt-inducible kinase 3
  2. Drug

    Miconazole

    go.drugbank.com/drugs/DB01110
    ApprovedInvestigationalVet approved

    [A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.

  3. Drug

    Magnesium gluconate

    go.drugbank.com/drugs/DB13749
    ApprovedWithdrawn

    Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts [L2608] and is used as a mineral supplement.

  4. Drug

    humanized SMART Anti-IL-12 Antibody

    go.drugbank.com/drugs/DB05848
    Experimental

    SMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that was licensed, together with certain intellectual property related to anti-IL-12 therapy, from Hoffmann-La Roche Inc … IL-12 is a cytokine that may have considerable potential as a target in the therapy of autoimmune diseases.

    Synonyms: humanized SMART Anti-IL-12 Antibody
  5. Indication

    Acute nephrosis

    go.drugbank.com/conditions/DBCOND0020416
    Drugs: Albumin human
    Synonyms: Acute TIN (tubulointerstitial nephritis)
  6. Drug

    Infliximab

    go.drugbank.com/drugs/DB00065
    ApprovedInvestigational

    Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by...

  7. Drug

    Rosemary oil

    go.drugbank.com/drugs/DB14689
    Approved

    Mixtures: Oil, OilSynonyms: Rosemary oil, Oil of rosemary
  8. Drug

    Curcumin

    go.drugbank.com/drugs/DB11672
    ApprovedInvestigational

    Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in [Curcuma xanthorrhiza oil].

  9. Drug

    Denenicokin

    go.drugbank.com/drugs/DB12908
    Investigational

    Denenicokin is under investigation in clinical trial NCT01152788 (Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma).

    Synonyms: IL-21 recombinant, Recombinant human IL-21
  10. Drug

    Gadoteric acid

    go.drugbank.com/drugs/DB09132
    ApprovedInvestigational

    Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA).