Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial,... Due to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell Lung Cancer (NSCLC).
- Mechanism
- Curator reviewed · 2 references
Curcumin acts as a scavenger of oxygen species, such as hydroxyl radical, superoxide anion, and singlet oxygen and inhibit lipid peroxidation as well as peroxide-induced DNA damage. Curcumin mediates potent anti-inflammatory agent and anti-carcinogenic actions via modulating various signalling molecules. It suppresses a number of key elements in cellular signal transduction pathways pertinent to growth, differentiation, and malignant transformation; it was demonstrated in vitro that curcumin inhibits protein kinases, c-Jun/AP-1 activation, prostaglandin biosynthesis, and the activity and expression of the enzyme cyclooxygenase (COX)-2.
- Primary indication
- No approved therapeutic indications.Curator reviewed
- Formula / weight
- C21H20O6 · 368.3799 g/mol (avg)
- Also known as
- Diferuloylmethane
- Code names
- E-100 · INS-100(I) · INS NO. 100(I) · NSC-32982
Resolves to
VFLDPWHFBUODDF-FCXRPNKRSA-NSMILESCOC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Curcumin, and which of those have an active Phase 3 trial?
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