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Displaying results 5611 - 5620 of 10000 in total
  1. Drug

    VPM1002

    go.drugbank.com/drugs/DB15801
    Investigational

    VPM1002 is a recombinant BCG vaccine candidate expressing listeriolysin and deficient in urease that is generated in the genetic background of BCG Prague as it has a better safety profile than some other … Because Hly is only active at an acidic pH, similar to listeriolysin O, the deletion of urease C was also beneficial for Hly to have optimal bioactivity in the phagosome.

  2. Drug

    4-Phenylfentanyl

    go.drugbank.com/drugs/DB09168
    ExperimentalIllicit

    4-Phenylfentanyl is a sythetic opioid derived from fentanyl. 4-Phenylfentanyl is around 8x the potency of fentanyl in analgesic tests on animals, but more complex 4-heteroaryl derivatives such as substituted … thiophenes and thiazoles are more potent still, as they are closer bioisosteres to the 4-carbomethoxy group of carfentanil.

  3. Drug

    XL820

    go.drugbank.com/drugs/DB05146
    Investigational

    XL820 is a solid. … growth factor receptor alpha, clinically validated targets implicated in a variety of human cancers.

  4. Drug

    TB-402

    go.drugbank.com/drugs/DB06050
    Investigational

    TB-402 is a human antibody binding to Factor VIII, which plays a crucial role in the coagulation of the blood. … It is expected to be developed as a potential treatment to prevent blood clot formation in connection with certain types of heart arrhythmia, such as atrial fibrillation.

  5. Drug

    PG-530742

    go.drugbank.com/drugs/DB05495
    Investigational

    PG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis. By inhibiting these MMPs, it potentially limits cartilage degradation and disease prog...

  6. Drug

    MIV-701

    go.drugbank.com/drugs/DB05736
    Experimental

    MIV-701 is a selective, potent inhibitor of the protease Cathepsin K. It is developed for the treatment of osteoporosis.

  7. Drug

    Rivoceranib

    go.drugbank.com/drugs/DB14765
    Investigational

    Rivoceranib is under investigation in clinical trial NCT02726854 (Apatinib as Second-line Treatment of Advanced Pancreatic Cancer).

  8. Drug

    ATX-01

    go.drugbank.com/drugs/DB18141
    Investigational

    ATX-01 is an antimiR, a chemically modified antisense oligonucleotide, designed to target microRNA 23b (miR-23b).

  9. Drug

    RP-A601

    go.drugbank.com/drugs/DB18339
    Investigational

    RP-A601 is an adeno-associated virus serotype rhesus 10 vector expressing the human galactocerebrosidase (GALC) gene

  10. Drug

    FBX-101

    go.drugbank.com/drugs/DB18340
    Investigational

    FBX-101 is an adeno-associated virus serotype rhesus 10 vector expressing the human galactocerebrosidase (GALC) gene