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AZD-0328
go.drugbank.com/drugs/DB12145InvestigationalAZD0328 has been used in trials studying the treatment and basic science of Schizophrenia and Alzheimer's Disease.
Categories: Heterocyclic Compounds, 1-RingErdafitinib
go.drugbank.com/drugs/DB12147ApprovedInvestigationaltool kit to treat such a prevalent medical condition. … [L5956, L5959] At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: BALVERSA 3 MG FÄ°LM KAPLI TABLET, 56 ADET, BALVERSA 3 MG FÄ°LM KAPLI TABLET, 84 ADETMenatetrenone
go.drugbank.com/drugs/DB12148InvestigationalMenatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.
Categories: Vitamin KBrincidofovir
go.drugbank.com/drugs/DB12151ApprovedInvestigational[A235725,A235735] Due to its formulation as a pro-drug brincidofovir also carries a greater bioavailability than cidofovir,[A235740,A235725] allowing for oral administration rather than intravenous. … It is a lipid conjugate pro-drug of the acyclic nucleotide analogue [cidofovir][L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and significantly reduces the nephrotoxicity
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Heterocyclic Compounds, 1-RingCiticoline
go.drugbank.com/drugs/DB12153ApprovedInvestigationalWithdrawnCiticoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides.
Categories: Heterocyclic Compounds, 1-RingSynonyms: Cytidine 5'-diphosphocholine, Cytidine-5'-diphosphocholineNapabucasin
go.drugbank.com/drugs/DB12155InvestigationalNapabucasin has been investigated for the treatment of Colorectal Carcinoma.
Categories: Heterocyclic Compounds, 2-RingFasinumab
go.drugbank.com/drugs/DB12157InvestigationalFasinumab is a human IgG1k monoclonal antibody targeted against nerve growth factor (NGF).
Filorexant
go.drugbank.com/drugs/DB12158InvestigationalFilorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.
Categories: Heterocyclic Compounds, 1-RingDupilumab
go.drugbank.com/drugs/DB12159ApprovedInvestigationalDupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. … [L7186] Dupilumab is commonly marketed as Dupixent, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017.
Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsProducts: DUPIXENT® 300MG, DUPIXENT® 200MGDeutetrabenazine
go.drugbank.com/drugs/DB12161ApprovedInvestigationalIt is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated [DB04844] [A32046]. … Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates