Search
Metabolism and Physiological Effects of N-Acetylhistidine
smpdb.ca/view/SMP0126711MetabolicSeveral proteins from prokaryotes and archaea are also modified by N-terminal acetylation. … In particular, N-Acetylhistidine can be biosynthesized from L-histidine and acetyl-CoA by the enzyme histidine N-acetyltransferase (EC 2.3.1.33).
Drugs: HistidineMetabolism and Physiological Effects of Beta-Alanine
smpdb.ca/view/SMP0126732MetabolicThe associated inhibition of GABA transaminase and displacement of GABA from CNS binding sites can also lead to GABAuria (high levels of GABA in the urine) and convulsions. … beta-Alanine is the only naturally occurring beta-amino acid - an amino acid in which the amino group is at the beta-position from the carboxylate group.
Metabolism and Physiological Effects of Indolelactic Acid
smpdb.ca/view/SMP0126749MetabolicIndolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine. … Tryptophan is metabolized by two major pathways in humans, either through kynurenine or via a series of indoles, and some of its metabolites are known to be biologically active.
Metabolism and Physiological Effects of 1-Methylhistidine
smpdb.ca/view/SMP0126760MetabolicSETD3-mediated histidine methylation appears to occur in all higher eukaryotes with actin, from plants to insects to vertebrates. Within cells, SETD3 is found in the cytoplasm and nucleus. … Approximately 75% of 1-methylhistidine in the human body is estimated to originate from skeletal muscle (3MH/1MH switch - PMID: 32235743 ).
Metabolism and Physiological Effects of Vanillic Acid
smpdb.ca/view/SMP0126881MetabolicThe deletion mutant of this protein can be used in production of natural vanillin by microbial fermentation from ferulic acid at final concentrations and molar yields on an industrial scale. … Vanillic acid, which is a chlorogenic acid, is an oxidized form of vanillin. It is also an intermediate in the production of vanillin from ferulic acid.
Nintedanib
go.drugbank.com/drugs/DB09079ApprovedInvestigationalbeing [Pirfenidone]) and as such is used as a first-line treatment following diagnosis to slow down the progressive loss of lung function. … Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).
Categories: Antineoplastic and Immunomodulating AgentsProducts: Nintedanib Capsules, 100 mg and 150 mg, OFEV SOFT CAPSULES 100MGMitoxantrone
go.drugbank.com/drugs/DB01204ApprovedInvestigationalAn anthracenedione-derived antineoplastic agent.
Categories: Anthracyclines and Related Substances, Antineoplastic and Immunomodulating AgentsProducts: MITOXANTRONE BAXTER SOLUTION FOR INJECTION 20MG/10ML (2MG/ML), Novantrone Inj 2mg/mlKetotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigational[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is … [A231204] Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis.
Categories: Decongestants and AntiallergicsProducts: Up and Up Eye Itch Relief, U-KEFEN TABLETS 1MGPrenylamine
go.drugbank.com/drugs/DB04825ApprovedWithdrawnPrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Categories: Calcium-Regulating Hormones and AgentsProducts: ELECOR 25MG, ELECOR 50MGHuman thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalFurthermore, human thrombin is manufactured by chromatographic purification of prothrombin from cryo-poor plasma followed by activation with calcium chloride [FDA Label]. … This transformation mimics the final coagulation cascade step which involves the clotting mass that adheres to the wound surface and achieves hemostasis and sealing of open tissues.
Products: THROMBIRAAS1000 UI