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Nelistotug
go.drugbank.com/drugs/DB19334InvestigationalNelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous Cell Carcinoma of the Head an...
Synonyms: Gamma1 heavy chain Homo sapiens (1-452) [VH(Homo sapiens IGHV1-69*01 (95.9%) -(IGHD)-IGHJ1*01 (90.9%) L123>T (117), CDR-IMGT [8.8.15](26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1, Nelistotug (immunoglobulin G1-kappa, anti-[Homo sapiens CD96 (T cell activation increased late expression, TACTILE, T-cell surface protein tactile)], Homo sapiens monoclonal antibody)Belimumab
go.drugbank.com/drugs/DB08879ApprovedInvestigational[L42630] Belimumab was first approved by the FDA on March 9, 2011,[A251495] making it the newest drug to be approved for the treatment of SLE in more than 50 years. … [A251495, L42705] By binding to BLyS and blocking its interaction with B cell receptors, belimumab inhibits the survival of B cells.
Products: BENLYSTA 120 MG IV INFUZYONLUK COZELTI HAZIRLAMAK ICIN TOZ ICEREN FLAKON, 1 ADET, BENLYSTA 120 MG POLVO LIOFILIZADO CONCENTRADO PARA SOLUCION PARA INFUSIONCysteamine
go.drugbank.com/drugs/DB00847ApprovedInvestigationalMarketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.[L15601] … [L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis.
Products: CYSTAGON ® 150 MG, CYSTAGON ® 50 MG CAPSULASBrinzolamide
go.drugbank.com/drugs/DB01194Approved[A2049,A2051] Although systemic anti-carbonic anhydrase (CA) therapy has been used for almost 50 years with varying degrees of success, systemic administration results in an increase in incidences of adverse … [A2051] Unlike [dorzolamide], brinzolamide has a higher lipophilicity to facilitate diffusion across the blood-retinal barrier.
Mixtures: BRİTİL-T 10 MG/ML + 5 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, AZARGA 10 MG/ML + 5 MG/MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesThiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalN,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. … It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsProducts: Tepasyl 100 mg İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 ADET, Tepharix 100 mg İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 adetFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalOnce bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. … Fondaparinux may be used: to prevent venous thromboembolism in patients who have undergone orthopedic surgery of the lower limbs (e.g. hip fracture, hip replacement and knee surgery); to prevent VTE in
Products: ARIXTRA 10 MG/0.8 ML S.C. ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR SIRINGA, 10 ADET, ARIXTRA 2.5 MG/0.5 ML ENJEKSIYONLUK SOL.10 KUL.HAZ.SIRINGADexibuprofen
go.drugbank.com/drugs/DB09213ApprovedWithdrawnIt is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. … For Metabolism, Enzymes, Carriers, Transporters Sections, refer to [Ibuprofen].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesProducts: XIALOX® 100 MG, TRADIL FORT 400 MG FILM TABLET, 10 ADETDiphenhydramine
go.drugbank.com/drugs/DB01075ApprovedInvestigationalAs histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the … Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539].
Mixtures: TANOL 100 ML LOSYON, GAYABEN 150 ML SURUPCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesRaludotatug deruxtecan
go.drugbank.com/drugs/DB19447InvestigationalRaludotatug deruxtecan is under investigation in clinical trial NCT06660654 (A Study of Raludotatug Deruxtecan in Participants With Advanced/metastatic Solid Tumors (Rejoice-pantumor01)).
Synonyms: immunoglobulin G1-kappa, anti-[Homo sapiens CDH6(cadherin 6, K-cadherin (foetal kidney), cadherin 6 type 2)], humanized monoclonal antibody conjugated to deruxtecan, comprising a linker and a camptothecinBetamethasone
go.drugbank.com/drugs/DB00443ApprovedInvestigationalVet approved[A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.
Mixtures: BRUMETON 1 MG/ML+100 MG/ML GÖZ DAMLASI, PSORCUTAN BETA 50 MCG/G + 500 MCG/G MERHEM , 30 GRCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Inducers