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Tamsulosin
go.drugbank.com/drugs/DB00706ApprovedInvestigational[A178351] Tamsulosin was first approved by the FDA on April 15, 1997.[L6238] … Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.
Mixtures: DUODART 0,5 MG/0,4 MG KAPSÜL,30 KAPSÜL, DUODART 0,5 MG/0,4 MG KAPSÜL,90 KAPSÜLCategories: Drugs Used in Benign Prostatic Hypertrophy, Peripheral alpha-1 blockersPrednisolone
go.drugbank.com/drugs/DB00860ApprovedInvestigationalVet approved[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]
Mixtures: OTIMISIN DAMLA, 10 MLSynonyms: Predniso(lo)ne, delta(1)-HydrocortisoneManidipine
go.drugbank.com/drugs/DB09238ApprovedInvestigationalWithdrawnIt is selective for vasculature and does not produce effects on the heart at clinically relevant dosages. … Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
Mixtures: VIVACE 30/10MG TABLETTEN, VIVACE 30/10MG TABLETTENCategories: Heterocyclic Compounds, 1-RingRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnRofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%. … The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2.
Categories: Heterocyclic Compounds, 1-Ring, COX-2 InhibitorsSynonyms: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanoneHepatitis B Vaccine (Recombinant)
go.drugbank.com/drugs/DB11627ApprovedInvestigationalWithdrawnIn Asia, infection often occurs early in life, leading to a hepatitis B marker prevalence of more than 70% in the general population and a carrier rate of up to 20%. … In Canada, the United States and Northern Europe, 4% to 6% of the population are infected during their lifetime (mostly young adults); between 5% and 10% of infections lead to persistent viremia (carrier
Mixtures: HEXAXIM 0.5 ML IM ENJEKSİYONLUK SÜSPANSİYON İÇEREN FLAKON, 10 ADET, HEXAXIM 0.5 ML IM ENJEKSİYONLUK SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR, 10 ADETProducts: ENGERIX-B 20 Mikrogramm/1 ml Injektionssuspension in einer Fertigspritze, HEPB ERİŞKİN 20 MCG/ 1 ML IM ENJEKSİYONLUK SÜSPANSİYON, 10 ADETDoxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … [L5977] Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant.[L5971] However, in 2010 it was approved for the treatment of insomnia.
Categories: Adrenergic alpha-1 Receptor Antagonists, Heterocyclic Compounds, 1-RingProducts: Rho-doxepin-10 Mg Cap, APO-DOXEPIN CAPSULE 10 mgNitrendipine
go.drugbank.com/drugs/DB01054ApprovedWithdrawnIt is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Mixtures: Baroprine 10 mg/20 mg Tabletten, Cenipres 10 mg/20 mg TablettenCategories: Heterocyclic Compounds, 1-RingSunitinib
go.drugbank.com/drugs/DB01268ApprovedInvestigationalIn addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3. … On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingProducts: SUNITINIB EG, Sunitinib 1A Pharma 50 mg - HartkapselnGemcitabine
go.drugbank.com/drugs/DB00441ApprovedInvestigationalIt is approved by the FDA to treat advanced ovarian cancer in combination with [carboplatin], metastatic breast cancer in combination with [paclitaxel], non-small cell lung cancer in combination with [ … [L32950] It is also being investigated in other cancer and tumour types.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one, 2'-Deoxy-2',2'-difluorocytidineSumatriptan
go.drugbank.com/drugs/DB00669ApprovedInvestigational[A179761] Sumatriptan was granted FDA approval on 28 December 1992.[L6805] … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines.
Categories: Heterocyclic Compounds, 2-Ring, Serotonin-1b and Serotonin-1d Receptor AgonistSynonyms: 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide, (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide