Nitrendipine is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
- Mechanism
- Curator reviewed
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
- Primary indication
- For the treatment of mild to moderate hypertensionCurator reviewed · 2 structured indications
- Formula / weight
- C18H20N2O6 · 360.3612 g/mol (avg)
- Code names
- BAY-E-5009
Resolves to
PVHUJELLJLJGLN-UHFFFAOYSA-NSMILESCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Nitrendipine, and which of those have an active Phase 3 trial?
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