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Displaying results 5881 - 5890 of 10000 in total
  1. Drug

    Rocatinlimab

    go.drugbank.com/drugs/DB18809
    Investigational

    Despite its promising results, the long-term safety of rocatinlimab requires further investigation, as serious adverse events and injection reactions such as fever and chills have been reported. … In clinical trials, it has shown significant efficacy and safety compared to a placebo.

    Categories: Amino Acids, Peptides, and Proteins
  2. Drug

    Seliciclib

    go.drugbank.com/drugs/DB06195
    Investigational

    Developed by Cyclacel, seliciclib is being researched for the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation … R-roscovitine (Seliciclib or CYC202) is a cyclin-dependent kinase (CDK) inhibitor that preferentially inhibits multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase of treated

  3. Drug

    HNM01

    go.drugbank.com/drugs/DB06531
    Experimental

    The drug hNM01, a humanized monoclonal antibody developed by SRD Pharmaceuticals, Inc., targets the V(3) region of the HIV-1 envelope protein gp120, functioning as an HIV replication inhibitor. … It entered Phase 1 clinical trials for the treatment of HIV infections but was discontinued during this phase

  4. Drug

    Lunacalcipol

    go.drugbank.com/drugs/DB05024
    Investigational

    Cytochroma anticipates that CTA018 will be more potent than currently marketed vitamin D analogues such as calcitriol and calcipotriol and it is expected to have a greater safety index. … This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and a potent activator of vitamin D signaling pathways.

  5. Drug

    Nafamostat

    go.drugbank.com/drugs/DB12598
    Investigational

    It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. … The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.

  6. Drug

    SSR-126517E

    go.drugbank.com/drugs/DB05362
    Experimental

    SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.

  7. Drug

    Befunolol

    go.drugbank.com/drugs/DB09013
    Experimental

    Befunolol is a beta blocker introduced in 1983 by Kakenyaku Kakko. It is currently in experimental status, and is being tested for the management of open angle glaucoma.

    Categories: Antiglaucoma Preparations and Miotics
  8. Drug

    Mesterolone

    go.drugbank.com/drugs/DB13587
    Investigational

    Mesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). … Mesterolone demonstrated to have minimal effect on sperm counts and levels of FSH or LH [A27177, A27178].

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  9. Drug

    Prednisolone sodium metazoate

    go.drugbank.com/drugs/DB05340
    Investigational

    ATL-2502(Colal-Pred) is an old drug (prednisolone metasulphobenzoate, a steroid) with a new delivery system that releases the medication only in the colon.

  10. Drug

    Vanoxerine

    go.drugbank.com/drugs/DB03701
    Investigational

    [A248555] Vanoxerine is an investigational drug and has not been approved for therapeutic use. … It was synthesized in the late 1970s and developed as a potential treatment for depression.