ATL-2502(Colal-Pred) is an old drug (prednisolone metasulphobenzoate, a steroid) with a new delivery system that releases the medication only in the colon. Releasing the drug directly into the colon reduces... Colal-Pred is being studied for use in ulcerative colitis.
- Mechanism
- Curator reviewed
ATL-2502 is the combination of Alizyme's proprietary colonic drug delivery system, colal, and prednisolone metasulfobenzoate sodium ("PMSBS"), an approved steroid in Europe. colal-PRED has a starch coating that is only broken down in the gut by bacteria occurring in the colon. This leads to topical delivery of PMSBS to the colon rather than systemic delivery with the objective of providing efficacy, but without the side effects of steroids; however, the efficacy and safety of colal-PRED must be shown in well-controlled, prospective clinical trials and approved by the FDA.
- Primary indication
- Investigated for use/treatment in inflammatory bowel disease and ulcerative colitis.Curator reviewed
- Formula / weight
- C28H31NaO9S · 566.595 g/mol (avg)
- Code names
- ATL-2502
Resolves to
RWFZSORKWFPGNE-UHFFFAOYSA-MSMILES[Na+].CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)COC(=O)C1=CC(=CC=C1)S([O-])(=O)=OWhat you can answer from here — as of April 02, 2026
Which drugs share a target with Prednisolone sodium metazoate, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account