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Vildagliptin
go.drugbank.com/drugs/DB04876ApprovedInvestigational[A232488] By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote … Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme.
Mixtures: JALRA ®M 50 MG /500 MG, JALRA ®M 50 MG /500 MGCategories: Glucagon-Like Peptide 1, P-glycoprotein substratesEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalEsomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer. … Esomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme
Synonyms: (S)-omeprazole, (S)-(−)-omeprazoleInternational brands: ES-ODGalantamine
go.drugbank.com/drugs/DB00674ApprovedInvestigational[L13571] It is therefore not considered to be a disease-modifying drug. … Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease
Mixtures: GALNORA 8MG + 16MG HKP RET, GALNORA 8MG + 16MG HKP RETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTilmicosin
go.drugbank.com/drugs/DB11471InvestigationalVet approvedTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with _Mannheimia haemolytica_.
Categories: P-glycoprotein substratesProducts: JinPlus 250 mg/ml Oral Liquid, VMT 250 mg/ml Oral SolutionGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationalIn the U.S. and Canada, golimumab is marketed under the brand name Simponi®. The FDA label includes a black box warning of serious infections and malignancy. … treatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe
Products: SIMPONI 50 MG, SIMPONI 50 MG ENJEKSİYONLUK COZELTİ ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADETEplerenone
go.drugbank.com/drugs/DB00700ApprovedInvestigationalEplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: INSPRA® 50 MG TABLETAS RECUBIERTAS, ACENOL® 25 MGKetotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigationalIt has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine]. … Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell stabilizing properties.
Categories: Heterocyclic Compounds, 1-RingProducts: ZADITEN ORAL DAMLA 1 MG/ML, 25 ML, Zatifex 1 mg/mL Oral Damla, Çözelti (25 mL)Pipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnHowever, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. … Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/ML, PIPOTAZ®25 MG/ ML SOLUCION INYECTABLEPimozide
go.drugbank.com/drugs/DB01100ApprovedA diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: NOROFREN 2 MG TABLET, 500 ADET, NOROFREN 2 MG TABLET, 20 ADETBuspirone
go.drugbank.com/drugs/DB00490ApprovedInvestigationalBuspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. … Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates
Synonyms: 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dioneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates