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Polymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxi...
Mixtures: OTEK-P EAR DROPS, PS-2261 Triple Antibiotic, 0.5gJNJ-55308942
go.drugbank.com/drugs/DB19110InvestigationalJNJ-55308942 is under investigation in clinical trial NCT05328297 (A Study of JNJ-55308942 in the Treatment of Bipolar Depression).
Categories: Purinergic P2 Receptor AntagonistsVipadenant
go.drugbank.com/drugs/DB06625InvestigationalCategories: Purinergic P1 Receptor AntagonistsNamodenoson
go.drugbank.com/drugs/DB12885InvestigationalNamodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma.
Categories: Purinergic P1 Receptor AgonistsDPCPX
go.drugbank.com/drugs/DB12946InvestigationalCPX has been used in trials studying the treatment of Cystic Fibrosis.
Categories: Purinergic P1 Receptor AntagonistsBinodenoson
go.drugbank.com/drugs/DB04853InvestigationalBinodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A2A receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective d...
Categories: Purinergic P1 Receptor AgonistsIstradefylline
go.drugbank.com/drugs/DB11757ApprovedInvestigationalIstradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates