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Tyramine

An important characteristic of this product is its impediment to cross the blood-brain barrier which restrains its side effects to only nonpsychoactive peripheral sympathomimetic effects. … There have been reports of hypertensive crisis in patients ingesting tyramine-rich diet in conjunction with monoamine oxidase inhibitors (MAOIs).

SPP 301

SPP301 (Avosentan) is a potent and highly selective ET[A] receptor blocker and is clinically investigated in diabetic nephropathy.

CHF 4227

CHF 4227 is a new selective estrogen receptor modulator (SERM). … The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis.

Adrenomedullin

Adrenomedullin is under investigation in clinical trial NCT06072118 (Adrenomedullin for CADASIL).

Iolopride I-123

Iolopride I-123 is a small molecule drug. The usage of the INN stem '-pride' in the name indicates that Iolopride I-123 is a sulpiride derivative and analogue. … Iolopride I-123 has a monoisotopic molecular weight of 400.06 Da.

Efalizumab

The FDA approved efalizumab in 2003. It was later withdrawn in 2009 due to a potential risk of progressive multifocal leukoencephalopathy (PML).[L43797] … Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.

Irsogladine

Irsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of Lafutidine and Irsogladine Maleate in Healthy Adult Volunteers).

Efprezimod alfa

CD24Fc is a biological immunomodulator originally developed to address graft-versus-host disease in stem cell transplantation in leukemia patients.

gamma-Tocopherol

gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics).

Diloxanide furoate