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Displaying results 671 - 680 of 10000 in total
  1. Drug

    Aphidicolin

    go.drugbank.com/drugs/DB17742
    Experimental

    Aphidicolin is an antimitotic and antiviral metabolite of the mould _Cephalosporium aphidicola_. It inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162]

    Synonyms: 8,11a-methano-11ah-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3r,4r,4ar,6as,8r,9r,11as,11bs)-, 9,15-cyclo-c,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3.alpha.,4.alpha.,5.alpha.,17.alpha.)-
  2. Drug

    Tarcocimab tedromer

    go.drugbank.com/drugs/DB18937
    Investigational

    Tarcocimab tedromer is under investigation in clinical trial NCT06270836 (A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Moderately

    Synonyms: Immunoglobulin G1 [240-alanine,241-alanine,243-alanine,449-cysteine], anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal OG1950 g1-chain), disulfide with human-Mus musculus, monoclonal OG1950 k-chain, (232®232'),(235®235')-
  3. Drug

    TG01 vaccine

    go.drugbank.com/drugs/DB17123
    Investigational

    Synonyms: 12-A-p21 RAS(5-21). 12-C-p21 RAS(5-21). 12-D-p21 RAS(5-21). 12-Rp21 RAS(5-21). 12-S-p21 RAS(5-21). 12-V-p21 RAS(5-21). 13-D-p21 RAS(5-21)
  4. Drug

    Rocbrutinib

    go.drugbank.com/drugs/DB19445
    Investigational

    Rocbrutinib is under investigation in clinical trial NCT05716087 (A Study of Rocbrutinib in Participants With Relapse or Refractory Mantle Cell Lymphoma).

    Synonyms: 2-Propenamide, N-[5-[[6-[2-(1,3,4,6,7,8-hexahydro-7,7-dimethyl-1-oxo-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3-(hydroxymethyl)-4-pyridinyl]-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl]amino]-2-[(2S)-2, N-[5-[[6-[2-(1,3,4,6,7,8-Hexahydro-7,7-dimethyl-1-oxo-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3-(hydroxymethyl)-4-pyridinyl]-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl]amino]-2-[(2S)-2-methyl-4-(tetrahydro
  5. Drug

    Rozibafusp Alfa

    go.drugbank.com/drugs/DB19233
    Investigational

    Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).

    Synonyms: IMMUNOGLOBULIN G2-KAPPA, ANTI-(HUMAN INDUCIBLE COSTIMULATOR (ICOS) LIGAND PROTEIN) HUMAN MONOCLONAL ANTIBODY, FUSED WITH TWO COPIES OF A TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B (TNFSF13B, B-CELL
  6. Drug

    Dapiglutide

    go.drugbank.com/drugs/DB19182
    Investigational

    Dapiglutide is under investigation in clinical trial NCT05788601 (Dapiglutide for the Treatment of Obesity).

    Synonyms: -glutamyl)- (a2>aib (2-methylalanine), d3>e, s7>t, d8>s, m10>l, n11>a, n16>k, l17>q, n24>a, t29>h)human glucagonlike peptide 2 (glp-2), L-ASPARTIC ACID, L-HISTIDYL-2-METHYLALANYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-SERYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-ALANYL-L-THREONYL-L-ISOLEUCYL-L-LEUCYL-L-.ALPHA.
  7. Drug

    Olezarsen

    go.drugbank.com/drugs/DB18728
    ApprovedInvestigational

    Olezarsen is an antisense oligonucleotide that targets the messenger RNA (mRNA) for apolipoprotein C-III (APOC3, apoC-III),[L52033] which is a key regulator of triglyceride levels in plasma, in the liver … [A264888,A264893] Olezarsen is conjugated to a ligand containing three N-acetyl-galactosamine (GalNAc) residues to enable its delivery to hepatocytes.

    Synonyms: DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-M5C-T-T-G-T-M5C-M5C-A-G-M5C-(2'-O-(2-METHOXYETHYL), ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.
  8. Drug

    Ripertamab

    go.drugbank.com/drugs/DB16314
    Investigational

    Ripertamab is under investigation in clinical trial NCT02772822 (A Study Comparing the Efficiency and Safety of S-chop(cyclophosphamide, Hydroxydaunomycin, Oncovin, and Prednisone) Versus R-CHOP in Untreated

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens ms4a1 (membrane-spanning 4-domains subfamily a member 1, cd20)), chimeric monoclonal antibody, Immunoglobulin igg1, anti-(human cd20 antigen) (human-mus musculus monoclonal disulfide sct400 .gamma.1-chain), disulfide with human-mus musculus monoclonal sct400 .kappa.-chain, dimer
  9. Drug

    Nalotimagene carmaleucel

    go.drugbank.com/drugs/DB19155
    Investigational

    Synonyms: Cells are derived from the haematopoietic stem cell (HSC) donor and are genetically modified ex vivo with a non-replicative SFCMM-3 gamma- retroviral vector derived from Mo, human culture expanded activated allogeneic T cells for adjunctive immunotherapy.
  10. Drug

    Fimaporfin

    go.drugbank.com/drugs/DB17253
    Investigational

    Synonyms: 4,4'-(15,20-diphenyl-7,8(or 12,13 or 17,18)-dihydro-21h,23h-porphine-5,10-diyl)bisbenzenesulfonic acid, mixture of three isomers a, b and c (25%, 50%, 25%)