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Displaying results 671 - 680 of 10000 in total
  1. Drug

    Vactosertib

    go.drugbank.com/drugs/DB15310
    Investigational

    Vactosertib is under investigation in clinical trial NCT03724851 (Vactosertib in Combination With Pembrolizumab in Metastatic Colorectal or Gastric Cancer).

    Synonyms: 2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]anilineCategories: Heterocyclic Compounds, 1-Ring
  2. Drug

    (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE

    go.drugbank.com/drugs/DB07717
    Experimental

    Synonyms: (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
  3. Drug

    Budesonide

    go.drugbank.com/drugs/DB01222
    ApprovedInvestigational

    Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]

    Mixtures: BUDEK PLUS® 200/6 MCG, BUDEK PLUS® 200/6 MCGCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  4. Drug

    OTL-102

    go.drugbank.com/drugs/DB18642
    Experimental

    OTL-102 consists of autologous CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene. … It is being investigated for the treatment of X-linked chronic granulomatous disease.

    Synonyms: Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene
  5. Drug

    Ascorbic acid

    go.drugbank.com/drugs/DB00126
    ApprovedInvestigationalNutraceutical

    Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. … A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables.

    Synonyms: L-Ascorbate, L-Ascorbic AcidMixtures: MENTONEX-C 200/100 MG EFERVESAN TABLET, 20 ADET, MENTONEX-C 200/100 MG EFERVESAN TABLET, 10 ADET
  6. Drug

    Simethicone

    go.drugbank.com/drugs/DB09512
    ApprovedInvestigational

    Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. … [A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308]

    Mixtures: M A L D I M, BROMUX D® 100/300 MG CÁPSULA.Categories: Compounds used in a research, industrial, or household setting
  7. Drug

    Rivabazumab pegol

    go.drugbank.com/drugs/DB17788
    Investigational

    Rivabazumab pegol is being investigated as a treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.[A259457]

    Synonyms: KB001-A, KB001-A (AN ANTI-PCRV PEGYLATED MONOCLONAL ANTIBODY FRAGMENT TO THE TYPE III SECRETION SYSTEM OF PSEUDOMONAS AERUGINOSA)
  8. Drug

    Berberine ursodeoxycholate

    go.drugbank.com/drugs/DB18111
    Investigational

    Synonyms: 9,10-dimethoxy-5,6-dihydro-2H,8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-ylium 3α,7β-dihydroxy-5β-cholan-24-oate, Cholan-24-oic acid, 3,7-dihydroxy-, ion(1-), (3α,5β,7β)-, 5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium (1:1)
  9. Drug

    Tomivosertib

    go.drugbank.com/drugs/DB15219
    Investigational

    Tomivosertib is under investigation in clinical trial NCT03318562 (A PD Study of Oral eFT508 in Subjects With Advanced TNBC and HCC).

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 6'-((6-Amino-4-pyrimidinyl)amino)-8'-methyl-2'H-spiro(cyclohexane-1,3'-imidazo(1,5-a)pyridine)-1',5'-dione
  10. Drug

    PEP0101

    go.drugbank.com/drugs/DB18572
    Experimental

    PEP0101 is a nanocomplex consisting of elastin-like polypeptides and a small interfering RNA (siRNA) designed to down-regulate the expression of EVI1 oncogene in cancer cells.

    Synonyms: Nanocomplex consisting of a small interfering RNA that targets the human EV11 oncogenic transcription factor and an elastin-like polypeptide drug carrier.