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Displaying results 6801 - 6810 of 10000 in total
  1. Drug

    Enalapril

    go.drugbank.com/drugs/DB00584
    ApprovedInvestigationalVet approved

    It was developed from a targeted research programmed using molecular modelling. … It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension.

    Synonyms: (S)-1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline, 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl esterMixtures: DUOPRES® 5 MG / 20 MG CÁPSULAS, DUOPRES ® 5 MG / 10 MG CÁPSULAS
  2. Drug

    Cinalukast

    go.drugbank.com/drugs/DB00587
    Experimental

    Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airw...

    Synonyms: 3'-((E)-2-(4-cyclobutyl-2-thiazolyl)vinyl)-2,2-diethylsuccinanilic acidCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Monobenzone

    go.drugbank.com/drugs/DB00600
    ApprovedWithdrawn

    Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. … It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause destruction of melanocytes and permanent depigmentation.

    Synonyms: 4-(Benzyloxy)phenol, 4-Benzyloxyphenol
  4. Drug

    Linezolid

    go.drugbank.com/drugs/DB00601
    ApprovedInvestigational

    Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. … [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor.

    Synonyms: N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamideCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Heterocyclic Compounds, 1-Ring
  5. Drug

    Medroxyprogesterone acetate

    go.drugbank.com/drugs/DB00603
    ApprovedInvestigational

    Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.

    Synonyms: (6α)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione, 6-alpha-Methyl-17-alpha-acetoxyprogesteroneMixtures: DIVICONT TABLETAS 1 MG/5 MG, FEMELIN®
  6. Drug

    Cisapride

    go.drugbank.com/drugs/DB00604
    ApprovedWithdrawn

    The FDA issued a warning letter regarding this risk to health care professionals and patients.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: GASTRON 1 MG/1 ML SÜSPANSİYON, 200 ML, GUARPOSID - 5
  7. Drug

    Cyclothiazide

    go.drugbank.com/drugs/DB00606
    Approved

    As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water.

    Synonyms: 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxideCategories: Heterocyclic Compounds, 2-Ring
  8. Drug

    Nafcillin

    go.drugbank.com/drugs/DB00607
    ApprovedInvestigational

    A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. … It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].

    Synonyms: (2S,5R,6R)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)penicillanic acidCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP3A Inducers
  9. Drug

    Rifabutin

    go.drugbank.com/drugs/DB00615
    ApprovedInvestigational

    A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.

    Synonyms: 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV, 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin SCategories: P-glycoprotein inducers, Cytochrome P-450 Substrates
  10. Drug

    Candoxatril

    go.drugbank.com/drugs/DB00616
    Experimental

    Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.

    Synonyms: [4(S)-cis]-4-[[[1-[3-[(2,3-dihydro-1H-Indeb5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]cyclohexanecarboxylic acid, 4-({1-[(S)-2-(indan-5-yloxycarbonyl)-3-(2-methoxy-ethoxy)-propyl]-cyclopentanecarbonyl}-amino)-cyclohexanecarboxylic acid