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MK-8777
go.drugbank.com/drugs/DB18904InvestigationalMK-8777 is under investigation in clinical trial NCT00610649 (Trial to Determine the Maximum Tolerated Dose (MTD) Based on Safety and Tolerability, of Org 26576 in Participants With Major Depressive Disorder
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5H,7H-PYRIDO(3,2-F)PYRROLO(2,1-C)(1,4)OXAZEPIN-5-ONE, 8,9,9A,10-TETRAHYDRO-, (9AS)-ADL-5859
go.drugbank.com/drugs/DB18910InvestigationalADL-5859 is under investigation in clinical trial NCT00626275 (Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: BENZAMIDE, N,N-DIETHYL-4-(5-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,4'-PIPERIDIN)-4-YL)-TBI-223
go.drugbank.com/drugs/DB18911InvestigationalTBI-223 is under investigation in clinical trial NCT06192160 (Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis).
Synonyms: CARBAMIC ACID, N-(((5S)-3-(3-FLUORO-4-(2-OXA-6-AZASPIRO(3.3)HEPT-6-YL)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-, METHYL ESTERElzovantinib
go.drugbank.com/drugs/DB18918InvestigationalElzovantinib is under investigation in clinical trial NCT03993873 (Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET).
Synonyms: 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecine-12-carbonitrile, 3-amino-14-ethyl-11-fluoro-4,5,6,7,13,14-hexahydro-7-methyl-4-oxo-, (7S)-Sibeprenlimab
go.drugbank.com/drugs/DB18919ApprovedInvestigationalSibeprenlimab is a Proliferation Inducing Ligand (APRIL) blocker.[L54633] APRIL is a member of the tumour necrosis factor superfamily that regulates and modulates activated B cells. … [A274853, A274858] Sibeprenlimab is a humanized immunoglobulin G2 (IgG2) monoclonal antibody produced by Chinese Hamster Ovary (CHO) cells.
Synonyms: Immunoglobulin g2, anti-(human proliferation-inducing ligand protein) (human monoclonal vis649 .gamma.2-chain), disulfide with human monoclonal vis649 .kappa.-chain, dimerRulonilimab
go.drugbank.com/drugs/DB18922InvestigationalRulonilimab is under investigation in clinical trial NCT05408221 (The Efficacy and Safety of Rulonilimab in Combination With Lenvatinib in Hepatocellular Carcinoma).
Synonyms: Immunoglobulin g1 (251-glutamine,298-alanine,429-leucine), anti-(human programmed cell death protein 1) (human-mus musculus monoclonal f520 .gamma.1-chain), disulfide with human-mus musculus monoclonalIchorcumab
go.drugbank.com/drugs/DB18930InvestigationalIchorcumab is under investigation in clinical trial NCT03251482 (A Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Participants Undergoing Elective Total Knee
Izuralimab
go.drugbank.com/drugs/DB18933InvestigationalIzuralimab is under investigation in clinical trial NCT05879185 (A Study of Xmab23104 in People With Sarcoma).
Synonyms: PDCD1 (PROGRAMMED CELL DEATH 1, PD-1, PD1, CD279)), M, C-TERMINAL FRAGMENT), (260->234'),(263->237')-Burfiralimab
go.drugbank.com/drugs/DB18935InvestigationalBurfiralimab is under investigation in clinical trial NCT06306339 (A Study to Assess the Efficacy and Safety of Burfiralimab (Hzvsf-v13) and DMRD (Disease-modifying Antirheumatic Drug)).
Synonyms: IMMUNOGLOBULIN G4, ANTI-(HUMAN VIMENTIN) (HUMAN-MUS MUSCULUS .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS .KAPPA.-CHAIN, DIMERPulocimab
go.drugbank.com/drugs/DB18938InvestigationalPulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma).
Synonyms: Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ak109 .gamma.1-chain), disulfide with human monoclonal ak109 .kappa.-chain, dimer