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Displaying results 691 - 700 of 5496 in total
  1. Drug

    Nelfinavir

    go.drugbank.com/drugs/DB00220
    ApprovedInvestigational

    It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.

    Products: Viracept -50mg, Viracept -250mg
  2. Drug

    Edaravone

    go.drugbank.com/drugs/DB12243
    ApprovedInvestigational

    [A254257] It has three tautomers. … [L44007] It was later approved for the treatment of amyotrophic lateral sclerosis (ALS) in Japan and South Korea in 2015, followed by the FDA approval in May 2017 [L41810] and Health Canada approval in

    Products: RADICAVA™ IV Concentrate Solution for Infusion 30mg/20mL
  3. Drug

    Halofantrine

    go.drugbank.com/drugs/DB01218
    ApprovedWithdrawn

    It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. … It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste.

    Products: Halfan - Tab 250mg
  4. Drug

    Methadone

    go.drugbank.com/drugs/DB00333
    ApprovedInvestigational

    However, it also has a unique pharmacokinetic profile. … At higher doses, methadone use can result in respiratory depression, overdose, and death.

    Products: Alphadone Syrup 10mg/ml, METADONA SOLUCIÓN ORAL 10MG/ML
  5. Drug

    Methylnaltrexone

    go.drugbank.com/drugs/DB06800
    ApprovedInvestigational

    It is also a weak CYP2D6 inhibitor. FDA approved in 2008.

    Products: Relistor Solution For Injection 12mg/0.6mL, RELISTOR (TM) (SUBCUTANEOUS INJECTION,12MG/0.6ML PER VIAL)
  6. Drug

    Favipiravir

    go.drugbank.com/drugs/DB12466
    ApprovedInvestigational

    Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. The antiviral targets RNA-dependent RNA polymerase (RdRp) enzyme...

    Products: Fabiflu 200mg Tablets, AVIGAN Film-Coated Tablets 200mg (Favipiravir)
  7. Drug

    Aminoglutethimide

    go.drugbank.com/drugs/DB00357
    ApprovedWithdrawn

    It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454) … It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer.

    Products: Cytadren Tab 250mg
  8. Drug

    Pioglitazone

    go.drugbank.com/drugs/DB01132
    ApprovedInvestigational

    [L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in vivo_ with little consequence … medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose[L11416] via agonism at

    Mixtures: OSENI FILM COATED TABLET 25MG/ 30MG, OSENI FILM COATED TABLET 25MG/ 15MGProducts: ACTOS 30MG TABLET, PIOLET 30MG TABLETS
  9. Drug

    Trimetrexate

    go.drugbank.com/drugs/DB01157
    Approved

    It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

    Products: Neutrexin Pws IV 25mg/vial
  10. Drug

    Golimumab

    go.drugbank.com/drugs/DB06674
    ApprovedInvestigational

    Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation...

    Products: SIMPONI 50MG ILO I E FER, SIMPONI 100MG FER