Halofantrine is an antimalarial used for the treatment of severe malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine.
- Mechanism
- Curator reviewed
The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite.
- Primary indication
- For treatment of Severe malariaCurator reviewed
- Formula / weight
- C26H30Cl2F3NO · 500.424 g/mol (avg)
- First approval
- Canada, 1996 · United States, 2006
- Code names
- DL-WR-171669
Resolves to
Clinical / RWD
Structure
InChIKey
FOHHNHSLJDZUGQ-UHFFFAOYSA-NSMILESCCCCN(CCCC)CCC(O)C1=C2C=CC(=CC2=C2C=C(Cl)C=C(Cl)C2=C1)C(F)(F)FWhat you can answer from here — as of September 23, 2026
6Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Halofantrine, and which of those have an active Phase 3 trial?
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