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Displaying results 7091 - 7100 of 10000 in total
  1. Drug

    XMT-1001

    go.drugbank.com/drugs/DB06069
    Investigational

    XMT-1001 is a polymer-based prodrug of camptothecin (CPT), a well-characterized topoisomerase I inhibitor with potent anti-tumor activity. … XMT-1001 has demonstrated an improved therapeutic window as compared with CPT and irinotecan in human tumor xenografts models

    Categories: Compounds used in a research, industrial, or household setting
  2. Drug

    Bafilomycin A1

    go.drugbank.com/drugs/DB06733
    Experimental

    The most commonly utilized bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. … The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus.

    Synonyms: Bafilomycin A1
  3. Drug

    Carbopol 974P

    go.drugbank.com/drugs/DB05384
    ApprovedWithdrawn

    Carbopol 974P is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens. … It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies.

    Categories: Compounds used in a research, industrial, or household settingProducts: LIQUIGEL UD 2.5MG/G EINZEL
  4. Drug

    Tiludronic acid

    go.drugbank.com/drugs/DB01133
    ApprovedVet approvedWithdrawn

    [A1923] Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone.[A202235] Tiludronic acid was granted FDA approval on 7 March 1997.[L4763] … [A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.

    Categories: Phospholipases A, antagonists & inhibitors
  5. Drug

    Barnidipine

    go.drugbank.com/drugs/DB09227
    Investigational

    after a 1-year and 2-year follow-up period in 91% of the patients who had an initial response to the drug [A7842]. … Compared to several other calcium antagonists which are racemates, the barnidipine compound consisting of a single enantiomer may offer a high degree of pharmacological selectivity [A31567].

  6. Drug

    AZD0947

    go.drugbank.com/drugs/DB04848
    Experimental

    As of March 2003, the drug was in phase II trials; however, as of October 2004, it no longer appeared on the company’s development pipeline. … AZD0947 is a K+ channel opener, which was under investigation by AstraZeneca for the treatment of overactive bladder.

  7. Drug

    Interferon alfacon-1

    go.drugbank.com/drugs/DB00069
    ApprovedWithdrawn

    This protein has a molecular weight of 19,434 daltons. … Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon.

  8. Drug

    Niguldipine

    go.drugbank.com/drugs/DB09239
    Experimental

    Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.

  9. Drug

    Mebenil

    go.drugbank.com/drugs/DB14728
    Experimental

    An obsolete fungicide used to control various pathogens on cereals and seed potatoes.

  10. Drug

    AV-101

    go.drugbank.com/drugs/DB12878
    Investigational

    AV-101 has been used in trials studying the treatment of Neuropathic Pain.