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Hepatitis B Vaccine (Recombinant)
go.drugbank.com/drugs/DB11627ApprovedInvestigationalWithdrawnIn Asia, infection often occurs early in life, leading to a hepatitis B marker prevalence of more than 70% in the general population and a carrier rate of up to 20%. … It is estimated that the reservoir of persistent hepatitis B surface antigen carriers amounts to 350 million people worldwide.
Synonyms: Hepatitis B antigen, Hepatitis B VaccineSalts: Hepatitis B virus subtype ADW HBSAG surface protein antigen, Hepatitis B virus subtype ADW2 HBSAG surface protein antigenArsenic trioxide
go.drugbank.com/drugs/DB01169ApprovedInvestigationalIn general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. … The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: ARSENICO TRIOSSIDO EG, TRISENOX 1 MG/1 ML IV INFÜZYON IÇIN KONSANTRE ÇÖZELTI IÇEREN AMPUL, 10 ADETAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. … It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleAlbutrepenonacog alfa
go.drugbank.com/drugs/DB13884ApprovedIt is currently marketed in the forms of 250, 500, 1000 and 2000 IU/vial.[L2305] … Albutrepenonacog alfa (rIX-RFP) is a recombinant fusion protein that links a recombinant coagulation factor IX (rFIX) with a recombinant human albumin (rAlbumin).
Synonyms: Coagulation factor IX (recombinant), albumin fusion protein, Coagulation Factor IX (Recombinant), Albumin Fusion Protein (rIX-FP)Products: ไอเดลวิออน 250, ไอเดลวิออน 500Pantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigationalPantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … As the binding of pantoprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, pantoprazole's duration of antisecretory effect persists
Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesOfatumumab
go.drugbank.com/drugs/DB06650ApprovedInvestigational[L12612] Although it has a similar molecular mechanism of action as [rituximab], another CD-20 monoclonal antibody used in the treatment of rheumatoid arthritis and B-cell non-Hodgkin's lymphoma, ofatumumab … [L12753] The FDA subsequently approved ofatumumab for the treatment of RMS on August 20, 2020.
Categories: CD20 (Clusters of Differentiation 20) inhibitorsProducts: Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET, ARZERRA 100 MG I.V. İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (3 ADET)Fibrinogen human
go.drugbank.com/drugs/DB09222ApprovedInvestigationalFibrinogen concentrate (human) is a hematological agent. It works by replacing a specific protein in the blood, fibrinogen (factor I), that helps with blood clotting. … It is a soluble plasma glycoprotein with a molecular weight of about 340 kDa and is a physiological substrate for three enzymes: plasmin, factor XIIIa, and thrombin.
Mixtures: EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml, TACHOSİL 5,5 MG/CM2 İNSAN FİBRİNOJENİ VE 2.0 IU/CM2 İNSAN TROMBİNİ İLAÇLI SÜNGERSynonyms: Factor I human, Coagulation Factor IFerric derisomaltose
go.drugbank.com/drugs/DB15617ApprovedInvestigational[A190528] Ferric derisomaltose is a form of iron used in the treatment of iron deficiency. This drug is a complex of iron (III) hydroxide and derisomaltose. … Ferric derisomaltose was developed by Pharmacosmos Therapeutics ad was granted FDA approval in January 2020.
Products: Diafer 50 mg/ml Injektionslösung, MONOFER® SOLUTION FOR INJECTION OR INFUSION 100 MG/MLMivacurium
go.drugbank.com/drugs/DB01226ApprovedWithdrawnMivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. … It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.
Categories: Heterocyclic Compounds, 2-RingProducts: MİVACRON 20 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ, 5 ADET, MIVACRON INJECTION 10 mg/5 mlAripiprazole
go.drugbank.com/drugs/DB01238ApprovedInvestigational[L45859] Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors. … Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ARIPIPRAZOLO EG, ILIMIT® 20 MG