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Spironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.
Categories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 InhibitorsProducts: SPIRONOLACTON 100MG AAA PH, ALDACTONE ATenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Mixtures: Ag-emtricitabine / Tenofovir Disoproxil FumarateCategories: P-glycoprotein inhibitors, P-glycoprotein substratesElm
go.drugbank.com/drugs/DB14258ApprovedElm is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Products: Nin Jiom Pei Pa KoaSotalol
go.drugbank.com/drugs/DB00489ApprovedInvestigationalSotalol is a methanesulfonanilide developed in 1960.[A178579] It was the first of the class III anti arrhythmic drugs.[A178579] Sotalol was first approved as an oral tablet on 30 October 1992. … [L6334] A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesInternational brands: Xi An LinDigoxin
go.drugbank.com/drugs/DB00390ApprovedInvestigational[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. … They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.[A178240]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inducersProducts: LANOXIN PG 62.5MCG TABLETS, LANOXIN-PG PAEDIATRIC/GERIATRIC TABLET 0.0625 mgRivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalRivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. … However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Ag-rivaroxaban, Ixobran 15 (Rivaroxaban Tablet Ph Eur 15mg)Insulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalDue to the added crystals, NPH insulin is typically cloudy when compared to other forms of insulin and has a neutral pH. … Human insulin is also available in an inhalable form, intended to be used as a bolus meal-time insulin.
Mixtures: HUMINSULIN PROFIL III F PE, HUMINSULIN PROFIL III F PECategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersTerbinafine
go.drugbank.com/drugs/DB00857ApprovedInvestigationalVet approvedTerbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. … [A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: Lamisil At, Lamisil ATAcyclovir
go.drugbank.com/drugs/DB00787ApprovedInvestigational[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. … Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: ACIC 250 PI VIA, ACIC 500 PI VIAArbutin
go.drugbank.com/drugs/DB11217ApprovedIt has also been used as an anti-infective for the urinary system as well as a diuretic [F43]. … Most commonly, it is an active ingredient in skincare and cosmetic products as a skin-lightening agent for the prevention of melanin formation in various skin conditions that involve cutaneous hyperpigmentation
Mixtures: Dr Young 2p Brightening UV Sun Block SPF50 PA, The Prestige BB SPF25 PA 2PlusSynonyms: p-hydroxyphenyl β-D-glucoside, p-hydroxyphenyl β-D-glucopyranoside