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Displaying results 811 - 820 of 6949 in total
  1. Target

    Somatostatin receptor

    go.drugbank.com/bio_entities/BE0010250
    TargetHumans

    Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. … Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

    Polypeptides: Somatostatin receptor type 1, Somatostatin receptor type 2Function: G protein-coupled receptor activity
  2. Target

    Cannabinoid receptor

    go.drugbank.com/bio_entities/BE0010258
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. … G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1, Cannabinoid receptor 2Function: cannabinoid receptor activity, cannabinoid receptor activity
  3. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release … Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alpha, Folate receptor betaSynonyms: Folate receptor 1, Folate receptor 2
  4. Target

    Adenosine receptor

    go.drugbank.com/bio_entities/BE0010284
    TargetHumans

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase … Receptor for adenosine (PubMed:29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase

    Polypeptides: Adenosine receptor A1, Adenosine receptor A2aFunction: G protein-coupled adenosine receptor activity, G protein-coupled adenosine receptor activity
  5. Target

    Apelin receptor

    go.drugbank.com/bio_entities/BE0013166
    TargetHumans

    G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis … When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199

    Polypeptides: Apelin receptorSynonyms: Angiotensin receptor-like 1, G protein-coupled receptor APJ
  6. Drug

    Tavolixizumab

    go.drugbank.com/drugs/DB15042
    Investigational

    Tavolixizumab is under investigation in clinical trial NCT02318394 (A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors).

    Synonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSTNFRSF4 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 4, OX40, CD134)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN (1-451) (CHIMERIC
  7. Drug

    Benzethonium

    go.drugbank.com/drugs/DB11125
    Approved

    Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and effective concentrations for the compound specified by the U.S.

    Products: Made for Men
  8. Indication

    Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

    go.drugbank.com/conditions/DBCOND0162925
    Drugs: Sacituzumab govitecan
    Synonyms: Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma, Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma
  9. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin Receptor AntagonistsProducts: RISPERDAL CONSTA FOR INJECTION 25 mg/vial, RISPERDAL CONSTA FOR INJECTION 37.5 mg/vial
  10. Drug

    Ferrous fumarate

    go.drugbank.com/drugs/DB14491
    ApprovedInvestigational

    Used in treatment of iron deficiency anemia.

    Mixtures: Se-Tan DHA, Se-Tan DHA