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Displaying results 8241 - 8250 of 10000 in total
  1. Drug

    Asparaginase Erwinia chrysanthemi

    go.drugbank.com/drugs/DB08886
    ApprovedInvestigational

    Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. … [L1448] L-asparaginase was first identified in 1963,[A236344] and there are different formulations of L-asparaginase, including [Asparaginase Escherichia coli] and a pegylated form of this enzyme, [Pegaspargase

    Synonyms: Erwinia L-asparaginase, L-asparaginase (Erwinia)
  2. Drug

    Carfilzomib

    go.drugbank.com/drugs/DB08889
    ApprovedInvestigational

    Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. … FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.[L39392]

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: KYPROLIS®, KARFIB®
  3. Drug

    Teduglutide

    go.drugbank.com/drugs/DB08900
    ApprovedInvestigational

    Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.

    Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 AnalogSynonyms: Gly(2)-GLP-2, (Gly2)GLP-2
  4. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.

    Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: DIFUMY-MS®240 MG CÁPSULAS DURA, YARDIX® 240MG
  5. Drug

    Ferric carboxymaltose

    go.drugbank.com/drugs/DB08917
    ApprovedInvestigational

    Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.

    Categories: Compounds used in a research, industrial, or household settingProducts: FERINJECT®, Ferinject® 50 mg iron/mL solution for injection/infusion
  6. Drug

    Perospirone

    go.drugbank.com/drugs/DB08922
    Investigational

    It is commonly present as the hydrated hydrochloride salt form. … It is also shown to be less associated with extrapyramidal symptoms as a side effect compared to [DB00502].

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: SM-9018, cis-N-(4-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)butyl)-1,2-cyclohexanedicarboximide
  7. Drug

    Amfecloral

    go.drugbank.com/drugs/DB08924
    Experimental

    It acts as a prodrug which splits to form amphetamine and chloral hydrate, similarly to clobenzorex and related compounds, except that the N-substituent, in this case, yields a compound that is active … Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes.

  8. Drug

    Arsthinol

    go.drugbank.com/drugs/DB08928
    Experimental

    Considered well tolerated when compared to other related trivalent organoarsenicals, arsthinol has even undergone recent studies as a potential anticancer agent. … Arsthinol (INN) is an antiprotozoal agent that was first synthesized by Ernst A.H. Friedheim in 1949 via the complexing of acetarsol with 2,3-dimercaptopropanol.

  9. Drug

    Macitentan

    go.drugbank.com/drugs/DB08932
    ApprovedInvestigational

    Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October 2021 for the treatment of PAH.[L39105] It was subsequently approved by the FDA in March 2024.

    Mixtures: OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  10. Drug

    Letosteine

    go.drugbank.com/drugs/DB08939
    Experimental

    Letosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.