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Displaying results 8501 - 8510 of 10000 in total
  1. Drug

    Salvinorin A

    go.drugbank.com/drugs/DB12327
    Investigational

    Salvinorin A has been investigated for the basic science of Pharmaceutical Preparations.

    Synonyms: Salvinorin A
  2. Drug

    Rucaparib

    go.drugbank.com/drugs/DB12332
    ApprovedInvestigational

    [A249240] The drug was later approved by the European Commission in May 2018.[L42185] It is currently used to treat recurrent ovarian and prostate cancer in adults.[L42155,L42185]. … Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
  3. Drug

    Amcipatricin

    go.drugbank.com/drugs/DB12333
    Investigational

    SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone … In preclinical models, SPK-843 shows in vitro inhibitory activity comparable to or better than that of Amphotericin B against Candida spp., Cryptococcus neoformans, and Aspergillus spp.

  4. Drug

    Navitoclax

    go.drugbank.com/drugs/DB12340
    Investigational

    Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer.

    Synonyms: (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-Trifluoromethanesulfonylbenzenesulfonamide
  5. Drug

    Nilofabicin

    go.drugbank.com/drugs/DB12347
    Investigational

    CG400549 has been used in trials studying the treatment of Skin Infection.

    Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    5-amino-1,3,4-thiadiazole-2-thiol

    go.drugbank.com/drugs/DB12348
    Investigational

    ATT has been investigated in Pulmonary Tuberculosis.

    Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Piclozotan

    go.drugbank.com/drugs/DB12361
    Investigational

    Piclozotan has been investigated for the treatment of Parkinson's Disease.

    Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor Agonists
  8. Drug

    Vestronidase alfa

    go.drugbank.com/drugs/DB12366
    ApprovedInvestigational

    Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. … The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as human beta-glucuronidase (GUS) [FDA Label].

  9. Drug

    AZD-3839

    go.drugbank.com/drugs/DB12368
    Investigational

    AZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  10. Drug

    Sotrastaurin

    go.drugbank.com/drugs/DB12369
    Investigational

    Sotrastaurin has been used in trials studying the basic science and treatment of Uveal Melanoma, Richter Syndrome, Prolymphocytic Leukemia, Recurrent Mantle Cell Lymphoma, and Recurrent Small Lymphocytic Lymphoma, among others.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring