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Naloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approved[A234594] More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. … [L33734] Kits commonly include the supplies necessary to treat an overdose in a non-medical setting such as alcohol swabs, syringes, a rescue breathing mask, and instructions for use.
Synonyms: 1-N-Allyl-14-hydroxynordihydromorphinone, 17-allyl-3,14-dihydroxy-4,5α-epoxymorphinan-6-oneMixtures: SUBOXONE 8 MG/2 MG DILALTI TABLET, 7 ADET, Suboxone 8 mg/2 mg sublingual tabletsPergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnIt is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. … Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease.
Categories: Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-2 Receptor AgonistsProducts: PERGOLID-NEURAX 1 MGDesflurane
go.drugbank.com/drugs/DB01189ApprovedInvestigationalDesflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as [methoxyflurane], [sevoflurane], [enflurane], or [isoflurane]. … It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.[A226883,A226888] Desflurane was granted FDA approval on 18 September 1992.[L30285]
Synonyms: 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane, (±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl etherCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesOxymorphone
go.drugbank.com/drugs/DB01192ApprovedVet approvedOn June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFlecainide
go.drugbank.com/drugs/DB01195ApprovedInvestigationalWithdrawnFlecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone].
Synonyms: N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamideCategories: MATE 1 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexEstramustine
go.drugbank.com/drugs/DB01196ApprovedWithdrawnA nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Synonyms: Estradiol 3-(N,N-bis(2-chloroethyl)carbamate), 17β-Estradiol 3-(bis(2-chloroethyl)carbamate)Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsBromocriptine
go.drugbank.com/drugs/DB01200ApprovedInvestigationalWithdrawnBromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity.
Synonyms: 2-bromo-α-ergokryptin, 2-bromo-α-ergocryptineCategories: P-glycoprotein inhibitors, P-glycoprotein substratesRifapentine
go.drugbank.com/drugs/DB01201ApprovedInvestigationalRifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian ...
Synonyms: 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycinCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersLevetiracetam
go.drugbank.com/drugs/DB01202ApprovedInvestigationalmake it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions. … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: LEVIPIL®1 G, LEVETIRACETAM 1 GMitoxantrone
go.drugbank.com/drugs/DB01204ApprovedInvestigationalAn anthracenedione-derived antineoplastic agent.
Synonyms: 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinoneCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index