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WU-CART-007
go.drugbank.com/drugs/DB18617InvestigationalWU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.
Synonyms: an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7Prizloncabtagene autoleucel
go.drugbank.com/drugs/DB18623InvestigationalC-CAR039 is an autologous Chimeric Antigen Receptors (CAR) T-cell therapy expressing CD19/CD20 bi-specific CAR.
Synonyms: autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a bispecific chimeric antigen receptor, an autologous Chimeric Antigen Receptors (CAR) T-cell therapy expressing CD19/CD20 bi-specific CARCTX120
go.drugbank.com/drugs/DB18625InvestigationalCTX120 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting B-cell maturation antigen.
Synonyms: allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting B-cell maturation antigenAB-201
go.drugbank.com/drugs/DB18629InvestigationalAB-201 is a CAR-NK cell therapy targeted against HER2.[L48340] It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.
Synonyms: Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15AVR-RD-05
go.drugbank.com/drugs/DB18631ExperimentalAVR-RD-05 is a gene therapy comprising genetically modified autologous stem cells transduced _ex vivo_ with a lentiviral vector encoding the human iduronate-2-sulfatase (IDS) enzyme.
Synonyms: Ex vivo, lentiviral vector (LV)-mediated, genetically modified autologous cell therapy intended for the stable provision of functional human iduronate-2-sulfatase (IDS) enzyme to subjects with Hunter syndromeALLO-715
go.drugbank.com/drugs/DB18640InvestigationalALLO-715 is an allogeneic chimeric antigen receptor T Cell therapy targeting B cell maturation antigen (BCMA).
Synonyms: Allogenic Chimeric Antigen Receptor T Cells Targeting B Cell Maturation Antigen (BCMA)OTL-102
go.drugbank.com/drugs/DB18642ExperimentalOTL-102 consists of autologous CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene. … It is being investigated for the treatment of X-linked chronic granulomatous disease.
Synonyms: Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox geneOTL-203
go.drugbank.com/drugs/DB18643InvestigationalOTL-203 is an autologous CD34+ enriched cell therapy that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase gene.
Synonyms: Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase geneEx vivo expanded autologous human corneal epithelial cells containing stem cells
go.drugbank.com/drugs/DB18660ApprovedWithdrawnHoloclar (_ex vivo_ expanded autologous human corneal epithelial cells containing stem cells) is a stem cell therapy used to treat limbal stem cell deficiencies.[L48375]
Synonyms: Ex vivo expanded autologous human corneal epithelial cells containing stem cellsRugonersen
go.drugbank.com/drugs/DB18662InvestigationalRugonersen is a locked nucleic acid antisense oligonucleotide under investigation for the treatment of Angelman Syndrome.