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Methotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigationalMethotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. … [A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients
Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acidCarisoprodol
go.drugbank.com/drugs/DB00395ApprovedIn January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential … for abuse in addition to a low risk of dependence [L5074].
Grazoprevir
go.drugbank.com/drugs/DB11575ApprovedGrazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … in combination with [DB11574] for genotypes 1a, 1b, and 4 of Hepatitis C [A19593].
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsAmbenonium
go.drugbank.com/drugs/DB01122ApprovedWithdrawnAmbenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Autologous peripheral blood-derived CD34+ cells
go.drugbank.com/drugs/DB16367ApprovedInvestigationalAutologous peripheral blood-derived CD34+ cells, or CLBS119 (a proprietary version being developed by Caladrius Biosciences, Inc.), are hematopoietic stem cells. … [L27741] It is also a cell therapy being investigated by Caladrius Biosciences in the clinical trial NCT04522817 (CLBS119 for Repair of COVID-19 Induced Pulmonary Damage).
Cresol
go.drugbank.com/drugs/DB11143ApprovedAt concentrations normally found in the environment however, cresols do not pose any significant risk for the general population. … Cresol is a hydroxytoluene that can be extracted naturally from coal tar or made synthetically. Pure cresol is a mixture of ortho-, meta-, and para- isomers.
Sirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigationalSirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island … [A13448] Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: LAM-001Saccharomyces cerevisiae
go.drugbank.com/drugs/DB10447ApprovedSaccharomyces cerevisiae is a fungus which can provoke allergic reactions. Saccharomyces cerevisiae is used in allergenic testing.
Mixtures: P3 Oa, P3 OaPhenyltoloxamine
go.drugbank.com/drugs/DB11160ApprovedIt is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. … Nevertheless, phenyltoloxamine is used to a fairly limited extent in contemporary medicine, with only very few products involving it as an active ingredient.
Mixtures: Dologesic DF, Sinutab Sa TabCoagulation factor X human
go.drugbank.com/drugs/DB13148ApprovedInvestigationalCoagulation Factor X (Human) solution is approved by the FDA for intravenous injection under the market name Coagadex which contains normally 100 IU/mL of coagulation Factor X derived from healthy donors … It is a two-chain glycoprotein with the molecular weight of approximately 59 kDa [A31472].
Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET