Coagulation factor X human is a coagulation factor used to treat Factor X deficiency to control bleeding. However its use is limited in the perioperative setting for the management of bleeding in major surgery in patients with moderate and severe hereditary Factor X deficiency.
- Mechanism
- Curator reviewed · 5 references
Factor X is an inactive zymogen that is synthesized in the liver, which can be activated by Factor IXa (via the intrinsic pathway) or by Factor VIIa (via the extrinsic pathway). It is composed of a light chain which contains the Gla (glutamic acid) domain and two epidermal growth factor domains, and a heavy chain that contains the catalytic serine protease domain. The conversion of inactive Factor X into the active form Factor Xa requires the cleavage of a 52-residue peptide from the heavy chain and the release of 52-residue activation peptide that contains the His236, Asp228 and Ser379 catalytic site. This activation step can occur through the extrinsic or intrinsic pathway and is considered to be the first step in the common pathway to fibrin formation.
Factor Xa plays a critical initiation step of the coagulation pathway by cleaving and activating prothrombin to thrombin in complex with FVa, Ca2+ and phospholipids. This complex is also known as the prothrombinase complex. Thrombin then acts upon soluble fibrinogen and Factor XIII to generate a cross-linked fibrin clot.
- Primary indication
- The human coagulation factor X is indicated in adults and children with hereditary Factor X deficiency for routine prophylaxis to reduce the frequency of bleeding episodes, on-demand treatment and control of bleeding episodes, and perioperative...Curator reviewed · 4 structured indications
- Formula / weight
- 59000.0 Da
- First approval
- Canada, 2007 · United States, 2013 · European Union, 2020
- Also known as
- Coagulation factor X · Coagulation factor X (human) · Factor X · Factor X (stuart prower factor) · Human coagulation factor X
- Brand names
Resolves to
What you can answer from here — as of June 15, 2026
Which drugs share a target with Coagulation factor X human, and which of those have an active Phase 3 trial?
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