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Sevabertinib
go.drugbank.com/drugs/DB21667ApprovedInvestigational[L54638] Sevabertinib functions as a reversible kinase inhibitor of human epidermal growth factor receptor 2 (HER2), also exhibiting activity against epidermal growth factor receptor (EGFR). … Sevabertinib is a kinase inhibitor indicated for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsDaraxonrasib
go.drugbank.com/drugs/DB22308ApprovedInvestigationalRAS variants rather than a single mutation. … [L64039,L64041] Because it targets a broad range of RAS genotypes, it treats tumors with or without an identified RAS mutation and does not require a companion diagnostic test.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesCEP-7055
go.drugbank.com/drugs/DB33587ExperimentalCategories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 3-RingKW-2449
go.drugbank.com/drugs/DB33595InvestigationalCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring