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TMC-310911
go.drugbank.com/drugs/DB15623InvestigationalTMC-310911 has shown marked activity against a variety of HIV-1 strains, including multi-PI-resistant strains, and may be less likely to generate resistance, making it a potentially desirable therapy for … [L12045] It is being investigated for use in HIV-1 infections.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingZilucoplan
go.drugbank.com/drugs/DB15636ApprovedInvestigationalZilucoplan is a 15 amino-acid, synthetic macrocyclic peptide. … It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein involved in the innate immune system to initiate inflammatory responses.
Synonyms: N2-ACETYL-L-LYSYL-L-VALYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-PHENYLALANYL-L-.ALPHA.-ASPARTYL-N-METHYL-L-.ALPHA.-ASPARTYL-3-METHYL-L-VALYL-L-TYROSYL-3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL-L-.ALPHA., .-(2-(((4S)-4-CARBOXY-1-OXO-4-(1-OXOHEXADECYL)BUTYL)AMINO)ETHYL)-.OMEGA.-HYDROXY-, 15-ETHER WITH N-ACETYL-L-LYSYL-L-VALYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-PHENYLALANYL-L-.ALPHA.Products: Zılbrysq 16,6 mg/0,416 mL SC Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (7 Adet), Zılbrysq 23 mg/0,574 mL SC Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (7 Adet)Ravidasvir
go.drugbank.com/drugs/DB15652InvestigationalRavidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection).
Categories: Heterocyclic Compounds, 2-RingIslatravir
go.drugbank.com/drugs/DB15653ApprovedInvestigational[A275492, L56138] Chemically, it is a deoxyadenosine analogue distinguished by a 4'-ethynyl group and a 2-fluoro substitution, which collectively enhance its metabolic stability and potency. … Islatravir is a first-in-class, highly potent nucleoside reverse transcriptase translocation inhibitor (NRTTI) used in combination therapy for the treatment of HIV-1 infection.
Synonyms: 4'-ethynyl-2-fluoro-2'-deoxyadenosineCategories: Heterocyclic Compounds, 2-RingFezolinetant
go.drugbank.com/drugs/DB15669ApprovedInvestigational[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms can significantly affect quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep … the kisspeptin, neurokinin B, and dynorphin (KNDy) neurons.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesZavegepant
go.drugbank.com/drugs/DB15688ApprovedInvestigationalZavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. … [L45505] CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways.
Synonyms: 1-piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-n-((1r)-1-((7-methyl-1h-indazol-5-yl)methyl)-2-(4-(1-methyl-4-piperidinyl)-1-piperazinyl)-2-oxoethyl)-Categories: MATE 1 Substrates, P-glycoprotein substratesSulfamethylthiazole
go.drugbank.com/drugs/DB15882ExperimentalSulfamethylthiazole is a sulfonamide antibacterial agent.[A275183]
Synonyms: 4-Amino-N-(4-methyl-2-thiazolyl)benzenesulfonamide, N(sup 1)-(4-Methyl-2-thiazolyl)sulfanilamideInternational brands: Toriseptin MNifekalant
go.drugbank.com/drugs/DB16008InvestigationalNifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection).
Synonyms: 6-((2-((2-Hydroxyethyl)(3-(p-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyluracilCategories: Heterocyclic Compounds, 1-Ring