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Ramucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalVEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target. … Ramucirumab is indicated for us in advanced gastric or gastro-esophageal junction adenocarcinoma as a single agent or in combination with paclitaxel after prior fluoropyrimidine- or platinum-containing
Categories: Vascular Endothelial Growth Factor Receptor 2 Antagonist, VEGF/VEGFR (Vascular Endothelial Growth Factor / -Receptor) inhibitorsProducts: CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/10ML, CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 500MG/50MLTirzepatide
go.drugbank.com/drugs/DB15171ApprovedInvestigationalagonist for this indication. … Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor
Categories: Glucose-dependent Insulinotropic Polypeptide Receptor AgonistProducts: Mounjaro 5 mg solution for injection in vial, Mounjaro 10 mg solution for injection in vialBenralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigationalIt is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells, macrophages and neutrophils. … Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils
Categories: Drugs for Obstructive Airway Diseases, Interleukin-5 Receptor alpha-directed Cytolytic AntibodyProducts: FASENRA SOLUTION FOR INJECTION 30MG/ML (PRE-FILLED SYRINGE), Fasenra 30mg Solution for Injection in Pre-filled PenBortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigationalBortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome ...
Products: Retrox 3.5mg Powder for Solution for Injection, MYBORTE POWDER FOR SOLUTION FOR INJECTION 3.5MG/VIALSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigational[A27262] Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid … Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling
Categories: Biologics for Rheumatoid Arthritis Treatment, Interleukin-6 Receptor AntagonistProducts: KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG, KEVZARA Solution for Injection in Pre-filled Pen 150mgLecanemab
go.drugbank.com/drugs/DB14580ApprovedInvestigational[A253962,L44547] On January 6, 2023, lecanemab was granted accelerated approval by the FDA for the treatment of Alzheimer’s Disease.[L44547] It was granted full FDA approval on July 6, 2023.
Products: LEQEMBI 100mg/mL concentrate for solution for infusion (2mL), LEQEMBI 100mg/mL concentrate for solution for infusion (5mL)Eravacycline
go.drugbank.com/drugs/DB12329ApprovedInvestigationalEravacycline has demonstrated superior potency to that of antibiotics that are currently being marketed for intraabdominal infections [A38727].
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: XERAVA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 50MG PER VIALDenosumab
go.drugbank.com/drugs/DB06643ApprovedInvestigationalfor fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in September 2011 and in men with osteoporosis at high risk for fracture in September 2012. … It further received additional indication approval to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for non-metastatic prostate cancer and women at high risk
Categories: Drugs for Treatment of Bone DiseasesProducts: XGEVA 120mg Solution for Injection, XGEVA Solution for Injection 120 mg/vialAtezolizumab
go.drugbank.com/drugs/DB11595ApprovedInvestigational[L146011] It is the first approved immunotherapy-based adjuvant regimen for Stage III dMMR colon cancer. … Atezolizumab is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for non-small cell lung cancer, small cell lung cancer, hepatocellular carcinoma, melanoma, alveolar soft part sarcoma, muscle
Categories: Programmed Death Receptor-1 Blocking Antibody, Programmed Death Receptor-1-directed Antibody InteractionsProducts: TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 840MG/14ML, Tecentriq 60mg/ml Concentrate for Solution for InfusionPegaspargase
go.drugbank.com/drugs/DB00059ApprovedInvestigational[L44667] Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. … [A255912,A255917] In February 1994, pegaspargase was approved by the FDA for the treatment of ALL in patients with hypersensitivity to native forms of L-asparaginase.[A255927]
Products: ONCASPAR POWDER FOR SOLUTION FOR INJECTION/INFUSION 750 U/ML, Oncaspar 750 U/ml powder for solution for injection/infusion