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Trastuzumab emtansine
go.drugbank.com/drugs/DB05773ApprovedInvestigationalTrastuzumab emtansine is marketed under the brand name Kadcyla and is indicated for use in HER2-positive, metastatic breast cancer patients who have already used taxane and/or trastuzumab for metastatic … disease or had their cancer recur within 6 months of adjuvant treatment.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Kadcyla 160 mg powder for concentrate for solution for infusion, Kadcyla 100 mg powder for concentrate for solution for infusionTranylcypromine
go.drugbank.com/drugs/DB00752ApprovedInvestigationalTranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. … A propylamine formed from the cyclization of the side chain of amphetamine.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Antidepressive Agents Indicated for DepressionSynonyms: (1R*,2S*)-2-phenylcyclopropan-1-amineMethoxy polyethylene glycol-epoetin beta
go.drugbank.com/drugs/DB09107ApprovedInvestigationalMethoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin.
Categories: Compounds used in a research, industrial, or household settingProducts: MIRCERA ROCHE 120 MCG/0,3 ML SC/IV ENJ. ICIN KULLANIMA HAZIR SIRINGA, MIRCERA ROCHE 150 MCG/0,3 ML SC/IV ENJ. ICIN KULLANIMA HAZIR SIRINGAZafirlukast
go.drugbank.com/drugs/DB00549ApprovedZafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. … It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily.
Categories: Drugs for Obstructive Airway DiseasesSynonyms: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide, cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamateHistamine
go.drugbank.com/drugs/DB05381ApprovedInvestigationalIt is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. … A depressor amine derived by enzymatic decarboxylation of histidine.
Mixtures: Md Science Cannabidiol, Md Science CannabidiolCategories: Heterocyclic Compounds, 1-Ring, Tests for Gastric SecretionVildagliptin
go.drugbank.com/drugs/DB04876ApprovedInvestigational, or a thiazolidinedione in patients with inadequate glycemic control following monotherapy. … [A232488] Oral vildagliptin was approved by the European Medicines Agency in 2008 for the treatment of type II diabetes mellitus in adults as monotherapy or in combination with [metformin], a sulfonylurea
Mixtures: Vildagliptin/Metformin 1A Pharma 50 mg/850 mg – Filmtabletten, Vildagliptin/Metformin 1A Pharma 50 mg/1000 mg - FilmtablettenCategories: Glucagon-Like Peptide 1, Heterocyclic Compounds, 1-RingBasiliximab
go.drugbank.com/drugs/DB00074ApprovedInvestigationalA recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also … It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes
Products: SIMULECT FOR INJECTION 20 mg/vial, SIMULECT 20 MG İNFÜZYON VEYA ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADETNitrazepam
go.drugbank.com/drugs/DB01595ApprovedA benzodiazepine derivative used as an anticonvulsant and hypnotic.
Synonyms: 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one, 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneProducts: NITRAZEPAM-NEURAX 10 MG, NITRAZEPAM AL 10Selumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigational[A193611] "The novel MEK 1/2 inhibitor, selumetinib, was initially approved solely for the treatment of pediatric patients with Neurofibromatosis type 1 (NF-1) and symptomatic, inoperable plexiform … [A193533] Following its initial FDA approval on April 10, 2020,[L49991] and Health Canada approval on August 23, 2022,[L49986] the regulatory landscape has evolved.
Categories: Mitogen-Activated Protein Kinase Kinase 1 InhibitorsProducts: Koselugo Hard Capsules 10 mg, Koselugo Hard Capsules 25 mgZopiclone
go.drugbank.com/drugs/DB01198ApprovedInvestigationalZopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate