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ABBV-514
go.drugbank.com/drugs/DB17586InvestigationalABBV-514 is in development for the treatment of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) as a single agent and in combination with a PD-1 inhibitor.[L45464]
Maridebart Cafraglutide
go.drugbank.com/drugs/DB19339InvestigationalMaridebart Cafraglutide is under investigation in clinical trial NCT05669599 (Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity
Synonyms: insulinotropic polypeptide receptor) [275-cysteine,295-cysteine,300-glycine,305-cysteine] (human γ1-chain), disulfide with human κ-chain, dimer, 275,275′-bis(thioether) with 7-37-glucagon-like peptide IAllovectin-7
go.drugbank.com/drugs/DB17439InvestigationalIt was discontinued after it failed to improve the objective response rate or overall survival versus first-line chemotherapy in malignant melanoma.[A255207] … Allovectin-7 or allovectin-7(r) is a lipid complex that contains the DNA sequences encoding HLA-B7 and beta-2 microglobulin.
KYV-101
go.drugbank.com/drugs/DB23168InvestigationalKYV-101 is under investigation in clinical trial NCT06152172 (CARTIMMUNE: Study of Patients With Autoimmune Diseases Receiving KYV-101).
Nifekalant
go.drugbank.com/drugs/DB16008InvestigationalNifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection).
TC-6987
go.drugbank.com/drugs/DB14854InvestigationalTC-6987 is under investigation in clinical trial NCT01296087 (TC-6987 for the Treatment of Mild to Moderate Asthma).
E59
go.drugbank.com/drugs/DB18372ExperimentalE59 is a humanized IgG1 low affinity allergic reactivity inhibiting (LARI) monoclonal antibody. It was developed by Sixal Inc.
Clesacostat
go.drugbank.com/drugs/DB18956InvestigationalClesacostat is under investigation in clinical trial NCT04321031 (Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)).
Dimepheptanol
go.drugbank.com/drugs/DB19094InvestigationalDimepheptanol is under investigation in clinical trial NCT00218127 (Treatment of Opioid/heroin Dependence: Comparison of Three Medication Dosing Regimens).
Coprelotamab
go.drugbank.com/drugs/DB16380InvestigationalCoprelotamab is under investigation in clinical trial NCT04170595 (Clinical Study of Recombinant Anti-her2 Humanized Monoclonal Antibody for Injection).