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Clesacostat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Data Packages
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Identification

Generic Name
Clesacostat
DrugBank Accession Number
DB18956
Background

Clesacostat is under investigation in clinical trial NCT04321031 (Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 502.571
Monoisotopic: 502.221620082
Chemical Formula
C28H30N4O5
Synonyms
  • 4-(6-methoxy-4-(7-oxo-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro(indazole-5,4'- piperidine)-1'-carbonyl)pyridin-2-yl)benzoic acid
  • Benzoic acid, 4-(6-methoxy-4-((1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro(5h-indazole-5,4'-piperidin)-1'-yl)carbonyl)-2-pyridinyl)-
External IDs
  • PF-05221304
  • PF05221304
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
752DF9PPPI
CAS number
1370448-25-1
InChI Key
LXZMHBHEXAELHH-UHFFFAOYSA-N
InChI
InChI=1S/C28H30N4O5/c1-17(2)32-25-21(16-29-32)14-28(15-23(25)33)8-10-31(11-9-28)26(34)20-12-22(30-24(13-20)37-3)18-4-6-19(7-5-18)27(35)36/h4-7,12-13,16-17H,8-11,14-15H2,1-3H3,(H,35,36)
IUPAC Name
SMILES
COC1=CC(=CC(=N1)C1=CC=C(C=C1)C(O)=O)C(=O)N1CCC2(CC1)CC1=C(N(N=C1)C(C)C)C(=O)C2

References

General References
Not Available
ChemSpider
114641970
BindingDB
50511112
ChEMBL
CHEMBL4567446
ZINC
ZINC000114805174

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedBasic ScienceFatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD / Nonalcoholic Steatohepatitis With Liver Fibrosis1somestatusstop reasonjust information to hide
2CompletedBasic ScienceFatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD / Steatohepatitis, Nonalcoholic1somestatusstop reasonjust information to hide
2CompletedTreatmentFatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD1somestatusstop reasonjust information to hide
2CompletedTreatmentFatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD / Steatohepatitis, Nonalcoholic1somestatusstop reasonjust information to hide
1CompletedBasic ScienceHealthy Normals1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 27, 2024 16:23 / Updated at June 28, 2024 04:46