Clesacostat

DB18956InvestigationalSmall molecule

Clesacostat is under investigation in clinical trial NCT04321031 (Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)).

Mechanism: Pharmacologically active on Acetyl-CoA carboxylase 1 and Acetyl-CoA carboxylase 2
Curator reviewed
Formula / weight: C₂₈H₃₀N₄O₅ · 502.571 g/mol (avg)
Also known as: 4-(6-methoxy-4-(7-oxo-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro(indazole-5,4'- piperidine)-1'-carbonyl)pyridin-2-yl)benzoic acid · Benzoic acid, 4-(6-methoxy-4-((1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro(5h-indazole-5,4'-piperidin)-1'-yl)carbonyl)-2-pyridinyl)-
Code names: PF-05221304

Resolves to

Compound

UNII752DF9PPPICAS1370448-25-1ChEMBLCHEMBL4567446

Structure

InChIKeyLXZMHBHEXAELHH-UHFFFAOYSA-NSMILESCOC1=CC(=CC(=N1)C1=CC=C(C=C1)C(O)=O)C(=O)N1CCC2(CC1)CC1=C(N(N=C1)C(C)C)C(=O)C2

Targets

Q13085ACACAO00763ACACB

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

7Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Clesacostat, and which of those have an active Phase 3 trial?

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