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OPC-28326
go.drugbank.com/drugs/DB05461ExperimentalIt is the only clinical compound with this profile. It is currently being investigated in the treatment of peripheral vascular diseases and Raynaud's syndrome. … At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2-adrenoceptors while having minimal action on systemic blood pressure, heart rate and coronary
Categories: Heterocyclic Compounds, 1-RingCarbomycin
go.drugbank.com/drugs/DB11383ExperimentalVet approvedThis antibacterial is obtained from _Streptomyces halstedii_ and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. … Carbomycin, also called magnamycin, is crystalline macrolide antibiotic.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: Carbomycin A, Magnamycin AMasitinib
go.drugbank.com/drugs/DB11526InvestigationalVet approvedMasitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. … In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-((4-METHYLPIPERAZIN-1-YL)METHYL)-N-(4-METHYL-3-((4-PYRIDIN-3-YL-1,3-THIAZOL-2-YL)AMINO)PHENYL)BENZAMIDESparfosic acid
go.drugbank.com/drugs/DB03459ExperimentalSparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen atom. … This substance is known to target aspartate carbamoyltransferase catalytic chain and CAD protein.
Synonyms: N-(phosphonacetyl)-L-aspartic acid, N-phosphonacetyl-L-aspartic acidNadide
go.drugbank.com/drugs/DB14128InvestigationalA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. … It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Categories: Heterocyclic Compounds, 2-RingSynonyms: Coenzyme I, Cozymase IRisvutatug rezetecan
go.drugbank.com/drugs/DB23560InvestigationalRisvutatug rezetecan (GSK5764227) is a novel investigational B7-H3-targeted antibody-drug conjugate. … It is under investigation in clinical trial NCT06885034 (A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers
JNJ-64400141
go.drugbank.com/drugs/DB24373InvestigationalJNJ-64400141 is a biologic drug. … JNJ-64400141 is under investigation in clinical trial NCT05242432 (A Study of Adenovirus Serotype 26.Respiratory Syncytial Virus.Pre-Fusion F (Ad26.RSV.preF)-Based Vaccine for Prevention of Respiratory
Synonyms: Adenovirus Serotype 26.Respiratory Syncytial Virus.Pre-Fusion FZatolmilast
go.drugbank.com/drugs/DB14790InvestigationalBPN-14770 is under investigation in clinical trial NCT02840279 (A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects).
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 4 InhibitorsIodine I-125
go.drugbank.com/drugs/DB14804InvestigationalIodine I-125 is under investigation in clinical trial NCT00079417 (Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma).
Synonyms: Iodine I-125Olendalizumab
go.drugbank.com/drugs/DB14834InvestigationalOlendalizumab is under investigation in clinical trial NCT01883544 (Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALXN1007 in Healthy Male and Female Subjects).