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Corynebacterium diphtheriae
go.drugbank.com/drugs/DB09877ApprovedInvestigationalThe vaccine is intramuscularly administered to provide active immunization against diphtheria in infants and children. … *Corynebacterium diphtheriae* toxin is extracted from the pathogenic actinobacterium *C. diphtheriae* that causes diphtheria.
Mixtures: Td-pur für Erwachsene und HeranwachsendePhysostigmine
go.drugbank.com/drugs/DB00981ApprovedIt can be applied topically to the conjunctiva. … It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Glutathione
go.drugbank.com/drugs/DB00143ApprovedInvestigationalNutraceuticalIt conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Mixtures: RE-GLUTATHIONE + VITAMIN C CapsuleAflibercept
go.drugbank.com/drugs/DB08885ApprovedInvestigational[A261281,A261286] Due to the 2 fused VEGFR, aflibercept has a higher affinity to the cognate ligands than the endogenous individual receptor. … [L47966,L47971] The intravitreal formulation, under the brand name EYELEA, was approved by the FDA for the treatment of retinopathy of prematurity in preterm infants in February 2023 and for the treatment
Progesterone
go.drugbank.com/drugs/DB00396ApprovedInvestigationalVet approvedProgesterone is used in various contraceptive preparations to prevent ovulation and fertilization [T481], [A175612] as well as in other formulations to promote and support pregnancy. … A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609].
Categories: Sex Hormones and Modulators of the Genital SystemProducts: GESTAGENO®100MG CÁPSULAS DE GELATINA BLANDA, GESTAGENO® 200 MG CÁPSULAS DE GELATINA BLANDAGadoteric acid
go.drugbank.com/drugs/DB09132ApprovedInvestigational[A263141,A263106] Gadoterate is approved by the FDA under the brand name DOTAREM on 20th March 2013 for intravenous uses with magnetic resonance imaging (MRI) in the brain (intracranial), spine, and … due to a decreased tendency of gadolinium dechelation.
Prasugrel
go.drugbank.com/drugs/DB06209ApprovedInvestigationalSimilar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. … R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing activation of the GPIIb/IIIa receptor complex.
Bortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigationalapoptosis of cancer cells, is thought to be the main mechanism of action of bortezomib. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and
Imipramine
go.drugbank.com/drugs/DB00458ApprovedInvestigationalImipramine may be used to treat depression and nocturnal enuresis in children [FDA Label]. … Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: SICOTONE - IFSA TABLETA DE 25 MG.Amphetamine
go.drugbank.com/drugs/DB00182ApprovedIllicitInvestigationalThis use derived into a large overproduction of amphetamine and all the surplus after the war finalized ended up in the black market, producing the initiation of the illicit abuse.[A18540] … [L5194] During World War II, amphetamine was used to promote wakefulness in the soldiers.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome