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Fidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigationalFidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by _Clostridioides_ (formerly _Clostridium_) _difficile_ in adult and pediatric patients over the age of 6 months. … [L11575] Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation.
Synonyms: Tiacumicin BCategories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsTaliglucerase alfa
go.drugbank.com/drugs/DB08876ApprovedTaliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. … It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.
Synonyms: prGC-DProducts: ELELYSO 200 U İNFÜZYONLUK SOLÜSYON İÇİN LİYOFİLİZE TOZ, 1 ADETBelimumab
go.drugbank.com/drugs/DB08879ApprovedInvestigationalBelimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. … [A251495, L42705] By binding to BLyS and blocking its interaction with B cell receptors, belimumab inhibits the survival of B cells.
Categories: Decreased B Lymphocyte Activation, B Lymphocyte Stimulator-specific InhibitorProducts: BENLYSTA 200 MG / 1 ML, BENLYSTA SUBCUTÁNEO 200 MG / 1 MLPerampanel
go.drugbank.com/drugs/DB08883ApprovedInvestigationalPerampanel is a noncompetitive AMPA glutamate receptor antagonist. … The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Synonyms: 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersGadoxetic acid
go.drugbank.com/drugs/DB08884ApprovedInvestigationalEthoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. … Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection.
Categories: Compounds used in a research, industrial, or household settingProducts: PRIMOVIST® SOLUCIÓN INYECTABLE, PRIMOVIST 0,25 MMOL/ML ENJEKSIYON ICIN COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADETOcriplasmin
go.drugbank.com/drugs/DB08888ApprovedWithdrawnOcriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. … Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved in October 17, 2012.
Arbaclofen
go.drugbank.com/drugs/DB08891InvestigationalIt is believed to be a selective gamma-amino butyric acid type B receptor agonist, and has been investigated as a treatment for autism spectrum disorder and fragile X syndrome in randomized, double blind … Arbaclofen, or STX209, is the R-enantiomer of baclofen.
Synonyms: (R)-4-amino-3-(4-chlorophenyl)butanoic acid, (R)-BaclofenPeginesatide
go.drugbank.com/drugs/DB08894ApprovedWithdrawnPeginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. FDA approved March 27, 2012. … Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself.
Categories: Compounds used in a research, industrial, or household settingRegorafenib
go.drugbank.com/drugs/DB08896ApprovedInvestigationalRegorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 201...
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexGlucarpidase
go.drugbank.com/drugs/DB08898ApprovedInvestigationalGlucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified _Escherichia coli_ bacteria. It is a 390-amino acid homodimer protein. … [A7476,A7477] After the discovery of certain bacteria with the capacity to inactivate folate analogs such as methotrexate, carboxypeptidase G was identified and Carboxypeptidase G1 was first isolated