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Givosiran
go.drugbank.com/drugs/DB15066ApprovedGivosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. … [L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder
Categories: Heterocyclic Compounds, 1-Ring, Aminolevulinate Synthase 1-directed RNA InteractionAgerafenib
go.drugbank.com/drugs/DB15068InvestigationalAgerafenib is under investigation in clinical trial NCT03052569 (Expanded Access to RXDX-105 for Cancers With RET Alterations).
Categories: Heterocyclic Compounds, 2-Ring, Proto-Oncogene Proteins B-raf, antagonists & inhibitorsELX-02
go.drugbank.com/drugs/DB15080InvestigationalELX-02 is under investigation in clinical trial NCT03309605 (Phase 1 Study of ELX-02 in Healthy Adult Subjects).
Categories: Heterocyclic Compounds, 1-Ring18-methoxycoronaridine
go.drugbank.com/drugs/DB15096Investigational18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients).
Categories: Heterocyclic Compounds, 2-RingCusatuzumab
go.drugbank.com/drugs/DB15100Investigational[A241975] Cusatuzumab is a humanized IgG1 antibody targeted against CD70. … An overexpression of CD70 can result in the proliferation of malignant cells and has been documented in a variety of solid and hematological malignancies.
Telisotuzumab vedotin
go.drugbank.com/drugs/DB15104ApprovedInvestigationalTelisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting … agent, via a protease-cleavable valine-citrulline linker.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsFludeoxyglucose
go.drugbank.com/drugs/DB15107InvestigationalFludeoxyglucose is under investigation in clinical trial NCT03262389 (Comparison of F-18 FDG and C-11 Acetate PET in Multiple Myeloma).
Transfluthrin
go.drugbank.com/drugs/DB15117InvestigationalTransfluthrin is under investigation in clinical trial NCT02394522 (Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)).
Categories: Compounds used in a research, industrial, or household settingPCS-499
go.drugbank.com/drugs/DB15122InvestigationalPCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients).
Categories: Heterocyclic Compounds, 2-RingSynonyms: Deuterated S-lisofyllinePonezumab
go.drugbank.com/drugs/DB15135InvestigationalPonezumab is under investigation in clinical trial NCT00607308 (A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease).