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Anti-inhibitor coagulant complex

go.drugbank.com/drugs/DB13151
ApprovedInvestigational

Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.

  1. Drug

    Andexanet alfa

    go.drugbank.com/drugs/DB14562
    Approved

    It also prevents andexanet alfa from taking up space on phospholipid surface membranes, so that native FXa may bind and assemble the prothrominase complex [A35558]. … andexanet alfa is eliminated through the removal of a 34-residue fragment containing Gla: via this truncation, andexanet alfa is unable to bind to membrane surfaces and assemble the prothrombinase complex

    Categories: CoagulantsSynonyms: rfXa Inhibitor Antidote
  2. Drug

    Antihemophilic factor human

    go.drugbank.com/drugs/DB13192
    ApprovedInvestigational

    The complex was developed by CSL Behring or Baxter Healthcare Corporation and approved in the 90s. … The small amount of VWF:Ag is used to purify factor VIII complex and then removed from the final preparation. The final purified concentrate contains albumin as a stabilizer.[L1053].

    Mixtures: von Willebrand Factor/Coagulation Factor VIII Complex (Human), von Willebrand Factor/Coagulation Factor VIII Complex (Human)Categories: Coagulants