Identification
- Summary
Anti-inhibitor coagulant complex is a medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B.
- Brand Names
- Feiba
- Generic Name
- Anti-inhibitor coagulant complex
- DrugBank Accession Number
- DB13151
- Background
Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.
- Type
- Biotech
- Groups
- Approved, Investigational
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Activated prothrombin complex concentrate
- Antiinhibitor coagulant complex
- Factor VIII bypassing fraction
- Factor VIII inhibitor bypassing activity
- Factor VIII inhibitor bypassing fraction
Pharmacology
- Indication
For use in the control of bleeding episodes, perioperative management, and routine prophylaxis against bleeding episodes in hemophilia A and B patients with inhibitors.Label It is not indicated in the absence of factor VIII or IX inhibitors.
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
FEIBA contains several clotting factors which act at various points in the caogulation cascade to promote thrombosis.1
- Mechanism of action
Factor VIIa present in FEIBA forms a complex with tissue factor and calcium which converts endogenous and FEIBA contained factor X to Xa 1 2. Endogenous and FEIBA contained factor Xa act as parrt of the prothrombinase complex to convert endogenous and FEIBA contained prothrombin to thrombin. Endogenous and FEIBA contained thrombin then cleave fibrinogen to insulouble fibrin and activate factor XIII which covalently cross-links fibrin to form a polymer mesh. FEIBA also contains factor IX and IXa which act as part of the tenase complex to convert factor X to Xa. Thrombin activates factor V, VII, and VIII as part of the amplification phase of the clotting cascade. These events promote the formation of blood clots to prevent or stop bleeding.
Target Actions Organism ACoagulation factor X agonistHumans AProthrombin agonistHumans AFibrinogen alpha chain cleavageHumans AFibrinogen beta chain cleavageHumans ACoagulation factor XIII A chain agonistHumans ACoagulation factor V agonistHumans ACoagulation factor VIII agonistHumans ACoagulation factor VII agonistHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Plasma half lives of included clotting factors are as follows 2: Prothrombin - 65h Factor VII - 5h Factor IX - 25h Factor X - 40h
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
FEIBA is associated with increased risk of thromboembolic events such as stroke, myocardial infarction, and deep vein thrombosis Label.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Abciximab. Acenocoumarol The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Acenocoumarol. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Anti-inhibitor coagulant complex. Alteplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Alteplase. Aminocaproic acid The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Anti-inhibitor coagulant complex. Ancrod The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Ancrod. Anistreplase The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Anistreplase. Antithrombin Alfa The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Antithrombin Alfa. Antithrombin III human The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Antithrombin III human. Apixaban The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Apixaban. 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Feiba Kit; Powder, for solution 2500 [USP'U]/50mL Intravenous Baxalta Incorporated 1986-01-31 Not applicable US 
Feiba Kit; Powder, for solution 1000 [USP'U]/20mL Intravenous Baxalta Incorporated 1986-01-31 Not applicable US Feiba Kit; Powder, for solution 500 [USP'U]/10mL Intravenous Baxalta Incorporated 1986-01-31 Not applicable US Feiba Kit 500 [USP'U]/20mL Intravenous Baxalta Incorporated 1986-01-31 Not applicable US Feiba Nf Kit 2500 [USP'U]/50mL Intravenous Baxalta Incorporated 1986-01-31 2017-11-30 US Feiba Nf Kit; Powder, for solution 650 unit / vial Intravenous Takeda Not applicable Not applicable Canada 
Feiba Nf Kit; Powder, for solution 1300 unit / vial Intravenous Takeda 1997-10-27 Not applicable Canada Feiba Nf Kit 1000 [USP'U]/20mL Intravenous Baxalta Incorporated 1986-01-31 2017-11-30 US Feiba Nf Kit; Powder, for solution 650 unit / vial Intravenous Takeda Not applicable Not applicable Canada Feiba Nf Kit 500 [USP'U]/20mL Intravenous Baxalta Incorporated 1986-01-31 2017-09-30 US
Categories
- ATC Codes
- B02BD03 — Factor viii inhibitor bypassing activity
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- CS849DUN3M
- CAS number
- Not Available
References
- General References
- External Links
- FDA label
- Download (1.22 MB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Hemophilia A With Inhibitors 1 4 Completed Treatment Congenital Hematological Disorder / Hemophilia A With Inhibitors / Hemophilia B With Inhibitors 1 4 Completed Treatment Hemophilia A 1 4 Completed Treatment Hereditary Factor VIII Deficiency Disease With Inhibitor 1 3 Completed Treatment Coronavirus Disease 2019 (COVID‑19) / Hemophilia A or B With Inhibitors 1 3 Completed Treatment Hemophilia A 1 3 Completed Treatment Hemophilia A / Hemophilia A or B With Inhibitors / Hemophilia B 1 3 Not Yet Recruiting Treatment Hemophilia A 1 2 Withdrawn Treatment Cardiac Diseases 1 2, 3 Completed Prevention Hemophilia A With Inhibitors 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit; powder, for solution Intravenous 1000 [USP'U]/20mL Kit; powder, for solution Intravenous 2500 [USP'U]/50mL Kit; powder, for solution Intravenous 500 [USP'U]/10mL Injection, powder, for solution Intravenous 50 u/ml Injection, powder, lyophilized, for solution Intravenous 1000 U Injection, powder, for solution Parenteral Injection, powder, for solution Intravenous 25 u/ml Kit Intravenous 1000 [USP'U]/20mL Kit Intravenous 2500 [USP'U]/50mL Kit Intravenous 500 [USP'U]/20mL Kit; powder, for solution Intravenous 1300 unit / vial Kit; powder, for solution Intravenous 3250 unit / vial Kit; powder, for solution Intravenous 650 unit / vial Injection, powder, for solution Intravenous 1000 iu/1vial Injection, powder, for solution Intravenous 500 iu/1vial - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
- Gene Name
- F10
- Uniprot ID
- P00742
- Uniprot Name
- Coagulation factor X
- Molecular Weight
- 54731.255 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Thrombospondin receptor activity
- Specific Function
- Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostas...
- Gene Name
- F2
- Uniprot ID
- P00734
- Uniprot Name
- Prothrombin
- Molecular Weight
- 70036.295 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Cleavage
- General Function
- Structural molecule activity
- Specific Function
- Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function ...
- Gene Name
- FGA
- Uniprot ID
- P02671
- Uniprot Name
- Fibrinogen alpha chain
- Molecular Weight
- 94972.455 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Cleavage
- General Function
- Structural molecule activity
- Specific Function
- Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function...
- Gene Name
- FGB
- Uniprot ID
- P02675
- Uniprot Name
- Fibrinogen beta chain
- Molecular Weight
- 55927.9 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Protein-glutamine gamma-glutamyltransferase activity
- Specific Function
- Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibr...
- Gene Name
- F13A1
- Uniprot ID
- P00488
- Uniprot Name
- Coagulation factor XIII A chain
- Molecular Weight
- 83266.805 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Copper ion binding
- Specific Function
- Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
- Gene Name
- F5
- Uniprot ID
- P12259
- Uniprot Name
- Coagulation factor V
- Molecular Weight
- 251701.245 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Oxidoreductase activity
- Specific Function
- Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
- Gene Name
- F8
- Uniprot ID
- P00451
- Uniprot Name
- Coagulation factor VIII
- Molecular Weight
- 267007.42 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Serine-type peptidase activity
- Specific Function
- Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, o...
- Gene Name
- F7
- Uniprot ID
- P08709
- Uniprot Name
- Coagulation factor VII
- Molecular Weight
- 51593.465 Da
References
- Turecek PL, Varadi K, Gritsch H, Schwarz HP: FEIBA: mode of action. Haemophilia. 2004 Sep;10 Suppl 2:3-9. [Article]
Drug created at November 18, 2016 21:27 / Updated at June 03, 2022 07:24