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Rilonacept
go.drugbank.com/drugs/DB06372ApprovedInvestigationalRilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. … Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome (FCAS)
Categories: Receptors, Interleukin-1 Type ISynonyms: IL-1 TRAP, IL-1-TRAPTagraxofusp
go.drugbank.com/drugs/DB14731ApprovedInvestigationalIt is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_. … Tagraxofusp is a CD123-directed cytotoxin.
Synonyms: Diphtheria toxin-il-3 fusion protein targeting IL-3 receptorNogapendekin alfa
go.drugbank.com/drugs/DB18740ApprovedInvestigationalNogapendekin alfa is a human IL-15N72D variant. … [A263617, A263622] Nogapendekin alfa, in combination with inbakicept, mimics the actions of IL-15, , stimulating the activation and proliferation of natural killer cells and CD8+ memory T cells, which
Synonyms: Fusion protein consisting of il-15n72d and il-15rasu/fc, IL-15N72DIL-2 pDNA
go.drugbank.com/drugs/DB05935ExperimentalVical incorporated has initiated a human Phase 1 study of an investigational method of delivering interleukin-2 (IL-2), a potent immune system stimulant, for patients with recurrent metastatic melanoma
Synonyms: IL-2 pDNAAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigationalAnakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. … This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.
Synonyms: IL-1RAProducts: Kıneret 100 mg/ 0.67 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör, 7 ADET, Kıneret 100 mg/ 0.67 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör, 28 ADETSatralizumab
go.drugbank.com/drugs/DB15762ApprovedInvestigationalSatralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on … [A218546,A218551] Satralizumab is thought to exert its therapeutic benefits by blocking IL-6 receptors and, subsequently, these inflammatory responses.
Synonyms: Humanised anti-IL-6 receptor monoclonal antibodyProducts: ENSPRYNG SOLUTION FOR INJECTION IN PREFILLED SYRINGE 120MG/1ML, ENSPRYNG 120 mg/1ml solution for injection in pre-filled syringeOprelvekin
go.drugbank.com/drugs/DB00038ApprovedInvestigationalWithdrawnOprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. … With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid long.
Synonyms: IL-11humanized SMART Anti-IL-12 Antibody
go.drugbank.com/drugs/DB05848ExperimentalSMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that was licensed, together with certain intellectual property related to anti-IL-12 therapy, from Hoffmann-La Roche Inc … IL-12 is a cytokine that may have considerable potential as a target in the therapy of autoimmune diseases.
Synonyms: humanized SMART Anti-IL-12 AntibodyInterleukin-10
go.drugbank.com/drugs/DB12880InvestigationalInterleukin-10 has been used in trials studying the prevention and treatment of Vasculitis, Pancreatitis, Bile Duct Diseases, Pancreatic Diseases, and Gallbladder Diseases, among others.
Synonyms: IL-10, IL-10 (nonglycosylated)Adakitug
go.drugbank.com/drugs/DB05484InvestigationalMDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. … HuMax-Inflam was also effective in reducing disease activity in palmoplantar pustulosis patients in a clinical study.
Synonyms: HuMax IL-8, HuMax-IL-8