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Enfuvirtide

go.drugbank.com/drugs/DB00109
ApprovedInvestigational

Enfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake. The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhi...

  1. Pathway

    Enfuvirtide Action Pathway

    smpdb.ca/view/SMP0125964
    Drug action

    Enfuvirtide inhibits the envelope glycoprotein by binding to the first heptad-repeat in the gp41 subunut. … Enfuvirtide is an HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals.

    Drugs: Enfuvirtide · Magnesium cation
  2. Indication

    Human Immunodeficiency Virus Type 1 (HIV-1)

    go.drugbank.com/conditions/DBCOND0042885
    Drugs: Cabotegravir · Doravirine · Enfuvirtide · Rilpivirine
  3. Drug

    Tifuvirtide

    go.drugbank.com/drugs/DB05413
    Investigational

    Tifuvirtide is the first members of a new class of anti-HIV drugs which is also called fusion inhibitors. It has received fast-track designation from the FDA and is in Phase I/II clinical testing.