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Eptifibatide

go.drugbank.com/drugs/DB00063
ApprovedInvestigational

Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.

  1. Pathway

    Eptifibatide Action Pathway

    smpdb.ca/view/SMP0000266
    Drug action

    Eptifibatide (also named Integrilin) is an anti-coagulant drug that is produced from Sistrurus miliarus barbouri, which can block platelet glycoprotein IIb/IIIa receptor to prevent platelet aggregation

    Drugs: Eptifibatide
    Enzymes: Eptifibatide
  2. Pathway

    Eptifibatide Action Pathway (new)

    smpdb.ca/view/SMP0126461
    Drug action

    In the blood vessel, eptifibatide causes a conformational change in the integrins on the surface of activated platelets. … Eptifibatide is a small peptide derived from rattlesnake venom that targets glycoprotein IIb/IIIa receptors on the outer membrane of platelets.

    Drugs: Eptifibatide · Von Willebrand factor human
  3. Indication

    Acute Coronary Syndrome (ACS)

    go.drugbank.com/conditions/DBCOND0032938
    Drugs: Acetylsalicylic acid · Clopidogrel · Eptifibatide