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Maraviroc

go.drugbank.com/drugs/DB04835
ApprovedInvestigational

Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the M...

  1. Pathway

    Maraviroc Action Pathway

    smpdb.ca/view/SMP0125985
    Drug action

    Maraviroc blocks HIV entry to the host cell by selectively binding to the human chemokine receptor (CCR5) present on the membrane of CD4 cells (T cells). … Maraviroc, known by the brand name Selzentry or Celsentri, is a chemokine receptor antagonist drug used to treat HIV-1 infections. It was developed by the drug company Pfizer.

    Drugs: Magnesium cation · Maraviroc
  2. Pathway

    Maraviroc Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174659
    Metabolic

    Metabolites of sildenafil are predicted with biotransformer.

    Drugs: Mesoheme · Maraviroc
  3. Indication

    CCR5-tropic Human Immunodeficiency Virus Type 1 (HIV-1) Infection

    go.drugbank.com/conditions/DBCOND0145704
    Drugs: Maraviroc
  4. Indication

    Human Immunodeficiency Virus Type 1 (HIV-1) Infection

    go.drugbank.com/conditions/DBCOND0045921
    Drugs: Abacavir · Atazanavir · Bictegravir · Cabotegravir · Cobicistat · Darunavir +25 more