Phenoxymethylpenicillin is a penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues. Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK.
- Mechanism
- Curator reviewed · 2 references
Phenoxymethylpenicillin inhibits the biosynthesis of cell wall mucopeptide by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are critical in the cell wall synthesis and maintenance, as well as cell division. This disrupts the third and last stage of bacterial cell wall synthesis. This subsequently leads to cell lysis.
- Primary indication
- Indicated for the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms, with the use of bacteriological studies (including sensitivity tests) and clinical response.Curator reviewed · 18 structured indications
- Formula / weight
- C16H18N2O5S · 350.39 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1968
- Also known as
- Oracillin · Penicillin Phenoxymethyl · Penicillin V · Penicillin-V · Phenoxomethylpenicillin
- Brand names
Resolves to
BPLBGHOLXOTWMN-MBNYWOFBSA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC1=CC=CC=C1)C(O)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Phenoxymethylpenicillin, and which of those have an active Phase 3 trial?
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