D-alanyl-D-alanine carboxypeptidase DacB

BE0000744ProteinEscherichia coli (strain K12)dacB

Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction. It is acted on by 9 drugs in DrugBank.

Gene name
dacB
UniProtKB entry
P24228Swiss-Prot
Cellular location
Periplasm
Residues / weight
477 residues · 51,798 Da
Also known as
3.4.16.4 · D-alanyl-D-alanine endopeptidase · DD-carboxypeptidase · DD-endopeptidase · PBP-4

Resolves to

Protein
UniProtP24228UniProt nameDACB_ECOLI
Gene
NCBI Gene947693GenBank41216
Pharmacology
KEGGecj:JW3149
Structure
PDB2EX2PDB2EX6PDB2EX8
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on D-alanyl-D-alanine carboxypeptidase DacB, how selective are they, and which programs against it are still in active trials?

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