Huperzine A

DB04864ApprovedInvestigationalWithdrawnSmall molecule

Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of... Recently in clinical trials in China, it has demonstrated neuroprotective effects.

Chemical structure of Huperzine A
Mechanism
Curator reviewed
Primary indication
Investigated for use/treatment in alzheimer's disease.Curator reviewed
Formula / weight
C15H18N2O · 242.3162 g/mol (avg)
Also known as
(-)-Huperzine A · Huperzine-A · L-huperzine A · Selagine
Code names
SPN-817

Resolves to

Compound
UNII0111871I23CAS102518-79-6ChEMBLCHEMBL395280ChEBI78330PubChem854026KEGGC09992
Clinical / RWD
RxNorm2267703
Structure
InChIKeyZRJBHWIHUMBLCN-YQEJDHNASA-NSMILES[H][C@@]12CC3=C(C=CC(=O)N3)[C@@](N)(CC(C)=C1)\C2=C\C
Targets
P22303ACHEP04746AMY2AP09917ALOX5

What you can answer from here — as of November 07, 2025

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
292Drug interactionsStructured to mechanism, not free text
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21Clinical trialsPhase, status and sponsor resolved per trial
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16+ReferencesStructured and connected to the statements they support
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